[1]姚国召,李志红△.四逆香苏乌贝散治疗反流性食管炎疗效研究*[J].陕西中医杂志,2019,(9):1190-1194.
　YAO Guozhao,LI Zhihong..Clinical observation on treatment of reflux esophagitis with Sini Xiangsu Wubei San[J].,2019,(9):1190-1194.
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四逆香苏乌贝散治疗反流性食管炎疗效研究*
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《陕西中医》杂志[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年9期
页码:
1190-1194
栏目:
临床研究
出版日期:
2019-09-05

文章信息/Info

Title:
Clinical observation on treatment of reflux esophagitis with Sini Xiangsu Wubei San
文章编号:
DOI:10.3969/j.issn.10007369.2019.09.011
作者:
姚国召1; 李志红2△
1.北京市第一中西医结合医院老年病院区中医科（北京 100103）；2.北京中医药大学东直门医院脾胃科（北京 100700）
Author(s):
YAO Guozhao ; LI Zhihong.
Traditional Chinese Medicine in the Geriatrics District,Beijing First Integrated Chinese and Western Medicine Hospital( Beijing 100103)
关键词:
肝胃不和; 反流性食管炎; 四逆散; 香苏散; 乌贝散; 疗效比较
Keywords:
Key words Liverstomach disharmony syndrome; Reflux esophagitis; Sini San; Xiangsu San; Wubei San; Comparison of curative effects
分类号:
R574
文献标志码:
A
摘要:
摘 要 目的:探讨应用四逆香苏乌贝散加减治疗肝胃不和型反流性食管炎的临床疗效。方法:依据纳入标准选取符合本病的门诊患者82例，以随机数字表法分为治疗组与对照组各41例。两组均予以西医常规治疗，治疗组同时给予四逆香苏乌贝散加减治疗；连续治疗 8周后，观察两组临床疗效、两组治疗前后中医证候积分比较、主要症状改善情况及主症消失时间、不良反应和复发情况。结果：治疗组的总有效率为92.7%，高于对照组的70.7%(P＜0.05)。治疗结束后治疗组的证候积分为（9.51±5.311）分，低于对照组的（12.56±6.038）分(P＜0.05)。治疗后治疗组主症反酸、烧心、胸骨后疼痛、嗳气的发生率（61.0%、58.6%、43.9%、39.0%）均低于对照组（80.5%、80.5%、65.9%、68.3%）(P＜0.05)。治疗后治疗组主症反酸、烧心、胸骨后疼痛、嗳气的消失时间（9.60±4.356、10.38±4.209、9.47±4.903、8.95±4.391）d明显低于对照组（17.00±2.098、17.00±3.207、16.22±3.801、15.54±3.382）d(P＜0.05)。治疗组和对照组内镜疗效总有效率分别为81.8%和75.6%，两组差异无统计学意义（P＞0.05）；两组在治疗期间未见明显不良反应；治疗结束后治疗组4周和8周后复发率（5.56%、15.00%）低于对照组（25.81%、38.46%），差异具有统计学意义 (P＜0.05)。 结论:对肝胃不和型的反流性食管炎患者应用四逆香苏乌贝散加减治疗具有较好的临床疗效，能快速、有效地减轻和改善临床症状，安全性好且复发率低，优于西医常规治疗方法。
Abstract:
Abstract Objective:To investigate the clinical effect of Sini Xiangsu Wubei San on disharmony esophagitis of liver and stomach.Methods:According to the inclusion criteria,82 outpatients with the disease were selected and divided into the treatment group and the control group by random number table method.Both groups were treated with conventional western medicine,and the treatment group was treated with Sini Xiangsu Wubei San.After 8 weeks of continuous treatment,the clinical efficacy of the two groups was observed,the TCM syndrome scores of the two groups before and after treatment were compared,and the improvement of main symptoms,disappearance time of main symptoms,adverse reactions and recurrence of the two groups were observed.Results:The total effective rate of the treatment group 92.7% was higher than that of the control group 70.7%(P＜0.05).After treatment,the symptom score of the treatment group was (9.51±5.311),lower than that of the control group (12.56±6.038) (P＜0.05).The incidence of acid regurgitation,heartburn,retrosternal pain and belching (61.0%,58.6%,43.9%,39.0%) in the treatment group was lower than that in the control group (80.5%,80.5%,65.9%,68.3%)(P＜0.05).After treatment,the disappearance time of acid regurgitation,heartburn,retrosternal pain and belching in the treatment group (9.60±4.356,10.38±4.209,9.47±4.903,8.95±4.391) d was significantly lower than that in the control group (17.00±2.098,17.00±3.207,16.22±3.801,15.54±3.382)d (P＜0.05).The total effective rate observed under endoscope was 81.8% in the treatment group and 75.6% in the control group.The differences between the two groups showed no statistical significance (P ＞0.05).No adverse reactions were observed in the two groups during the treatment.The recurrence rate (5.56%,15.00%) in the treatment group was lower than that in the control group (25.81%,38.46%) at 4 weeks and 8 weeks after the end of treatment, the difference was statistically significant〖LM〗(P＜0.05).Conclusion:The application of Sini Xiangsu Wubei San in the treatment of patients with reflux esophagitis with disharmony between liver and stomach has good clinical efficacy,can rapidly and effectively reduce and improve clinical symptoms,has good safety and low recurrence rate,and is better than the conventional treatment of western medicine.

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备注/Memo

备注/Memo:
*吴阶平医学基金会临床科研专项资助项目（320.6750.17233）
更新日期/Last Update: 2019-09-24