[1]李世霞,张旭辉,李红梅,等.肺纤维化中内质网应激作用机制及中医药防治研究进展[J].陕西中医杂志,2023,(12):1819-1822,1826.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.034]
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肺纤维化中内质网应激作用机制及中医药防治研究进展
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《陕西中医》杂志[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年12期
页码:
1819-1822,1826
栏目:
综 述
出版日期:
2023-12-05

文章信息/Info

作者:
李世霞1张旭辉2李红梅2杨亚茹1
(1.甘肃中医药大学,甘肃 兰州 730000; 2.甘肃中医药大学附属医院,甘肃 兰州 730099)
关键词:
肺纤维化 肺痿 肺痹 内质网应激 未折叠蛋白反应 信号通路
分类号:
R 563
DOI:
DOI:10.3969/j.issn.1000-7369.2023.12.034
文献标志码:
A
摘要:
肺纤维化(PF)是一种慢性、进行性、致死性的间质性肺疾病,具体发病机制目前尚未阐明,西医缺乏有效治疗手段,且伴随诸多不良反应。中医理论认为PF病位在肺,发病以肺络虚损为主,气阴两伤,影响脾肾二脏,同时伴有痰浊、瘀血、毒邪等症,治疗当通补肺络,益气养阴,兼顾脾肾,同时佐以化痰、活血祛瘀、解毒祛邪之法。中医药治疗PF有辨证论治特色优势,而且不良反应少,较易被患者接受。内质网应激(ERS)被证实参与了PF的发生发展,诸多学者对基于ERS的中医药防治PF做了大量研究,证实无论是单味中药及有效成分还是中药复方或制剂均可通过调控ERS而延缓PF进展。现概括中医药基于ERS防治PF的研究进展,以期为今后进一步的研究提供相关理论依据。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82260889); 甘肃省自然科学基金资助项目(20JR5RA165); 兰州市城关区科技计划项目(2021SHFZ0026)
更新日期/Last Update: 2023-12-08