[1]李伦甘,胡玉英.中医药干预对帕金森病细胞凋亡影响的研究进展[J].陕西中医,2021,(2):262-264,268.[doi:DOI:10.3969/j.issn.1000-7369.2020.02.031]
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中医药干预对帕金森病细胞凋亡影响的研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年2期
页码:
262-264,268
栏目:
综述
出版日期:
2021-02-05

文章信息/Info

作者:
李伦甘1胡玉英2
(1.广西中医药大学,广西 南宁 530001; 2.广西中医药大学第一附属医院,广西 南宁 530023)
关键词:
帕金森病 细胞凋亡 Bcl-2基因家族 Caspase基因家族 中医药
分类号:
R 742
DOI:
DOI:10.3969/j.issn.1000-7369.2020.02.031
文献标志码:
A
摘要:
帕金森病(PD)是一种常见于中老年人的运动障碍性疾病,以黑质致密部多巴胺(DA)能神经元及其他含色素神经元(如蓝斑、脑干中的中缝核及迷走神经背核等)大量变性死亡为主要的病理特征。细胞凋亡作为一种多基因调控的程序性细胞死亡,参与了PD神经元细胞的死亡过程,线粒体介导的凋亡是PD细胞凋亡的主要途径,抗凋亡治疗是早期预防和延缓PD进程的一种有效治疗方法。中医药在抗细胞凋亡治疗上疗效明显,大量实验表明中医药干预,包括单味中药、中药复方及针灸等治疗,能通过多种机制调控凋亡相关基因(如抗凋亡基因Bcl-2和Bcl-xL、促凋亡基因Bax和P53等)信号转导,减少Caspases凋亡蛋白的激活及表达,从而抑制PD细胞凋亡。本文将对细胞凋亡分子机制及中医药干预对PD细胞凋亡影响的研究进展做一综述。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81960842)
更新日期/Last Update: 2021-01-28