[1]孙玉苹,尹明亮,王文艳,等.四妙勇安汤对糖尿病足部溃疡患者血清lncRNA MALAT1表达量及足背血流动力学的影响[J].陕西中医,2023,(8):1056-1060.[doi:DOI:10.3969/j.issn.1000-7369.2023.08.013]
　SUN Yuping,YIN Mingliang,WANG Wenyan,et al.Effect of Simiao Yong'an decoction on serum lncRNA MALAT1 expression and dorsal foot hemodynamics in patients with diabetic foot ulcers[J].,2023,(8):1056-1060.[doi:DOI:10.3969/j.issn.1000-7369.2023.08.013]
点击复制

四妙勇安汤对糖尿病足部溃疡患者血清lncRNA MALAT1表达量及足背血流动力学的影响
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年8期
页码:
1056-1060
栏目:
临床研究
出版日期:
2023-08-05

文章信息/Info

Title:
Effect of Simiao Yong'an decoction on serum lncRNA MALAT1 expression and dorsal foot hemodynamics in patients with diabetic foot ulcers
作者:
孙玉苹1; 尹明亮2; 王文艳3; 周 苗3; 王 超1; 吕育才1; 王传德1; 赵亚男1
(1.淄博市第一医院,山东 淄博 255200; 2.淄博万杰肿瘤医院,山东 淄博 255200; 3.上海市中医医院,上海 200071)
Author(s):
SUN Yuping; YIN Mingliang; WANG Wenyan; ZHOU Miao; WANG Chao; LYU Yucai; WANG Chuande; ZHAO Yanan
(The First Hospital of Zibo City,Zibo 255200,China)
关键词:
糖尿病;  足部溃疡;  四妙勇安汤;  长链非编码核糖核酸肺癌转移相关转录本1;  血流动力学;  炎症因子
Keywords:
Diabetes mellitus;  Foot ulcer;  Simiao Yong'an decoction;  lncRNA metastasis-associated lung adenocarcinoma transcript 1;  Hemodynamics;  Inflammatory factor
分类号:
R 587.2
DOI:
DOI:10.3969/j.issn.1000-7369.2023.08.013
文献标志码:
A
摘要:
目的:分析四妙勇安汤对糖尿病足部溃疡患者血清长链非编码核糖核酸(lncRNA)肺癌转移相关转录本1(MALAT1)表达量及足背血流动力学的影响。方法:选取150例糖尿病足部溃疡患者进行回顾性研究,根据治疗方法将其分为两组,每组75例,对照组给予常规西药治疗,观察组在对照组基础上给予四妙勇安汤治疗,比较两组临床疗效、症状体征评分、血清lncRNA MALAT1表达量、血清炎性因子、足背血流动力学指标、肉芽组织形成时间、创面愈合时间。结果:观察组临床总有效率高于对照组(P<0.05)。观察组治疗后色泽、渗出、疼痛、面积积分低于对照组(均P<0.05)。观察组治疗后血清lncRNA MALAT1表达量、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平低于对照组(均P<0.05)。观察组治疗后足背动脉血管内径高于对照组,足背动脉血流速度低于对照组(均P<0.05)。观察组肉芽组织形成时间、创面愈合时间短于对照组(均P<0.05)。结论:四妙勇安汤可有效缓解糖尿病足部溃疡患者坏疽、疼痛等症状,降低血清lncRNA MALAT1表达量,减轻炎症反应,改善足部血液循环,促进肉芽组织生长,缩短创面愈合时间。
Abstract:
Objective:To analyze the effects of Simiao Yong'an decoction on serum long chain non-coding RNA(lncRNA)metastasis-associated lung adenocarcinoma transcript 1(MALAT1)expression and dorsal foot hemodynamics in patients with diabetic foot ulcer.Methods:150 patients with diabetic foot ulcers were selected for retrospective study,and they were divided into two groups according to different treatment methods,75 cases in each group.The control group was given conventional western medicine treatment,and the observation group was given Simiao Yong'an decoction on the basis of the control group.The clinical efficacy,symptom and sign scores,serum lncRNA MALAT1 expression,serum inflammatory factors,dorsal foot hemodynamic indexes,granulation tissue formation time and wound healing time were compared between the two groups.Results:The total clinical effective rate of observation group was higher than that of control group(P<0.05).The scores of color,exudation,pain and area in the observation group were lower than those in the control group after treatment(all P<0.05).After treatment,the serum lncRNA MALAT1 expression,tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in observation group were lower than those in control group(all P<0.05).The internal diameter of dorsal foot artery in the observation group was higher than that in the control group,and the blood flow velocity of dorsal foot artery in the observation group was lower than that in the control group(all P<0.05).Granulation formation time and wound healing time of observation group were shorter than those of control group(all P<0.05).Conclusion:Simiao Yong'an decoction can effectively relieve gangrene,pain and other symptoms in diabetic foot ulcers,reduce serum lncRNA MALAT1 expression,reduce inflammatory response,improve foot blood circulation,promote the growth of granulation tissue,and shorten wound healing time.

参考文献/References:

[1] Al-Jalodi O,Kupcella M,Breisinger K,et al.A multicenter clinical trial evaluating the durability of diabetic foot ulcer healing in ulcers treated with topical oxygen and standard of care versus standard of care alone 1 year post healing[J].Int Wound J,2022,19(7):1838-1842.
[2] 冯海霞,彭新宇,董 峰.阳和汤加减联合银离子敷料治疗糖尿病足溃疡临床研究[J].陕西中医,2021,42(7):900-902.
[3] 林立英,陈雪芳.益气活络生肌汤促糖尿病足溃疡面的愈合作用研究[J].中华中医药学刊,2020,38(4):255-258.
[4] 张忠伟,洪 文,向立斌,等.长链非编码RNA肺腺癌转移相关转录本1在调控肝细胞癌的进程和化疗耐药中的机制研究[J].实用临床医药杂志,2022,26(3):81-90.
[5] 俞 华,梁从蝶,胡小华,等.尿毒清颗粒辅助治疗早期糖尿病肾病对机体氧化/抗氧化平衡及血清LncRNA KCNQ1OT1、LncRNA Malat1的影响[J].检验医学与临床,2022,19(24):3334-3338.
[6] 董学刚,刘 磊,高 岩,等.五味消毒饮联合“煨脓长肉法”治疗糖尿病足后病原菌分布及药物敏感性分析[J].四川中医,2021,39(12):122-127.
[7] 中国医疗保健国际交流促进会糖尿病足病分会,国际血管联盟中国分部糖尿病足病专家委员会.中国糖尿病足诊治指南[J].中国临床医生杂志,2020,48(1):19-27.
[8] 中国医师协会中西医结合医师分会内分泌与代谢病学专业委员会.糖尿病足病中医病证结合诊疗指南[J].中医杂志,2021,62(12):1099-1104.
[9] 于天一,梁学威,赵 钢.疮疡Ⅰ号外敷治疗湿热毒盛型糖尿病足部溃疡的临床观察[J].中国中西医结合外科杂志,2022,28(2):248-251.
[10] 苏海玉,石 钟,张宏颖,等.当归补血汤合二妙散加减联合负压封闭引流治疗糖尿病足疗效及对炎症因子、踝肱指数的影响[J].现代中西医结合杂志,2021,30(14):1548-1551.
[11] Lo ZJ,Chandrasekar S,Yong E,et al.Clinical and economic outcomes of a multidisciplinary team approach in a lower extremity amputation prevention programme for diabetic foot ulcer care in an Asian population:A case-control study[J].Int Wound J,2022,19(4):765-773.
[12] Davanzo J,Hartzman A,Surfield C,et al.Cryopreserved placental membrane allograft reduces the likelihood of developing a new or recurring foot ulcer and all-cause mortality in diabetic patients when compared with other cellular-and tissue-based products[J].Adv Wound Care(New Rochelle),2023,12(4):169-176.
[13] 王忠标,张佩朵,王永明.长链非编码RNA MALAT1、miR-29在糖尿病肾病中的表达及其临床意义[J].中国卫生检验杂志,2021,31(8):955-958.
[14] 王 旭,佘明明.活血生肌汤联合自体骨髓血干细胞移植对糖尿病足创面的修复作用研究[J].陕西中医,2019,40(10):1364-1366.
[15] 何本阳,谢银芳.参芪活血汤联合α-硫辛酸治疗2型糖尿病下肢血管病变对患者下肢血管血流量及NF-κB、VEGF的影响[J].四川中医,2021,39(4):129-133.
[16] 李艺博,张悦健,李 娟,等.四妙勇安汤“异病同治”动脉粥样硬化与血栓闭塞性脉管炎机制研究[J].世界中医药,2021,16(18):2663-2671.
[17] 王晓锋,张立新,张晓乐.长链非编码RNA肺腺癌转移相关转录因子1表达水平与颅内动脉瘤血管内治疗后复发的关系研究[J].介入放射学杂志,2021,30(11):1157-1161.
[18] 张鹏玉,燕 艳,付希英,等.长链非编码RNA在成人隐匿性自身免疫性糖尿病和2型糖尿病中的靶基因研究[J].中国糖尿病杂志,2021,29(5):328-333.
[19] 鞠佳桂,易 敏.分泌型卷曲相关蛋白5、长链非编码RNA人肺腺癌转移相关转录本、脂肪因子网膜蛋白-1在妊娠糖尿病患者中的表达及其对妊娠结局的预测价值[J].中国性科学,2021,30(11):96-99.
[20] 胡晓卫,屈 凯,沈 璐,等.全血糖化血红蛋白A1c、血清高敏C反应蛋白、血清脂蛋白(a)联合检测在糖尿病血管并发症诊治中的临床应用[J].陕西医学杂志,2020,49(1):118-120,124.
[21] 张 俊,张立文,李和平.血清高敏C反应蛋白和免疫球蛋白E检测在糖尿病酮症酸中毒电解质紊乱中的应用价值[J].陕西医学杂志,2022,51(6):737-740.
[22] 刘 湘,张 玥,公茂旺,等.基于网络药理学的四妙勇安汤治疗深静脉血栓形成机制研究[J].海南医学院学报,2021,27(11):855-860,867.

相似文献/References:

[1]罗荔.降糖饮联合西药治疗儿童1型糖尿病44例[J].陕西中医,2016,(10):1299.
[2]单亮亮,邓小敏,王振刚,等.五味消渴方治疗糖尿病机理探析[J].陕西中医,2017,(06):783.
[3]王巍,赵平.参芪麦味地黄汤联合运动疗法对妊娠期糖尿病气阴两虚型患者 糖脂代谢及妊娠结局的影响*[J].陕西中医,2018,(10):1339.
[4]王颖.益气降糖饮联合胰岛素对妊娠期糖尿病孕妇血糖、 内脂素水平及妊娠结局的影响*[J].陕西中医,2018,(10):1342.
　Wang Ying..Effects of Yiqi Jiangtang decoction combined with insulin on blood glucose， visfatin level and pregnancy outcome in patients with gestational diabetes mellitus[J].,2018,(8):1342.
[5]张 新.益气养血汤联合痔炎冲洗灵治疗肛周脓肿合并糖尿病患者切开〖JZ〗对口引流挂线术后创面愈合的影响[J].陕西中医,2019,(3):368.
[6]刘 辉,王连伟,乔 飞,等.知柏地黄汤联合个体化营养支持治疗糖尿病合并肺结核疗效及对患者T淋巴细胞亚群的影响*[J].陕西中医,2019,(1):76.
[7]杨 敏,姜钧文,肖 蕾.中医体质与急性心肌梗死及其危险因素的相关性研究*[J].陕西中医,2019,(4):437.
　YANG Min,JIANG Junwen,XIAO Lei..Study on the correlation between constitution of traditional Chinese medicine and acute myocardial infarction and its risk factors[J].,2019,(8):437.
[8]秦福芳,阎 磊,申凤娟,等.血必净注射液治疗老年糖尿病合并急性肾盂肾炎疗效研究[J].陕西中医,2019,(4):456.
　QIN Fufang,SHEN Fengjuan,SHAO Fengmin..Effect of Xuebijing injection on acute pyelonephritis in elderly patients with diabetes[J].,2019,(8):456.
[9]刘 扬,韩家凯,王 前.麝香养心散治疗糖尿病合并冠状动脉粥样硬化性心脏病 及对患者血脂、血流变与凝血功能的影响*[J].陕西中医,2019,(5):576.
　LIU Yang,HAN Jiakai,WANG Qian..Effect of Shexiang Yangxin powder on diabetic mellitus complicated with coronary atherosclerotic heart disease and its influence on blood lipid, hemorheological index and coagulation function〖WT4”BZ〗[J].,2019,(8):576.
[10]何 丽,朱亚丽,罗 方,等.盐酸帕罗西汀片联合养阴益气中药治疗糖尿病合并抑郁症 疗效研究*[J].陕西中医,2019,(5):645.
　HE Li,ZHU Yali,LUO Fang,et al.Effects of paroxetine hydrochloride tablets combined with Yangyin Yiqi TCM on SDS，DQOL and TESS score in diabetic patients with depression[J].,2019,(8):645.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82004369); 上海中医药大学产业发展中心医养结合科创项目(YYKC-2021-01-142)
更新日期/Last Update: 2023-08-10