[1]何 丽,朱亚丽,罗 方,等.盐酸帕罗西汀片联合养阴益气中药治疗糖尿病合并抑郁症 疗效研究*[J].陕西中医杂志,2019,(5):645-647.
　HE Li,ZHU Yali,LUO Fang,et al.Effects of paroxetine hydrochloride tablets combined with Yangyin Yiqi TCM on SDS，DQOL and TESS score in diabetic patients with depression[J].,2019,(5):645-647.
点击复制

盐酸帕罗西汀片联合养阴益气中药治疗糖尿病合并抑郁症 疗效研究*
分享到：

《陕西中医》杂志[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年5期
页码:
645-647
栏目:
临床研究
出版日期:
2019-05-05

文章信息/Info

Title:
Effects of paroxetine hydrochloride tablets combined with Yangyin Yiqi TCM on SDS，DQOL and TESS score in diabetic patients with depression
文章编号:
DOI:〖HT5K〗10.3969/j.issn.1000-7369.2019.05.029
作者:
何 丽; 朱亚丽; 罗 方; 李皓雲; 张丰姣; 刘红梅; 李 蕾; 李凤丽
郑州大学附属郑州中心医院内分泌科(郑州 450052)
Author(s):
HE Li; ZHU Yali; LUO Fang; et al.
Department of Endocrinology,Zhengzhou Central Hospital Affiliated to Zhengzhou University (Zhengzhou 450000)
关键词:
糖尿病; 抑郁症; 盐酸帕罗西汀片; 养阴益气中药; 抑郁自评量表; 血糖
Keywords:
Diabetes; Depression;  Palatine hydrochloride tablets; Traditional Chinese medicine; SDS; Blood glucose
分类号:
R749.41
文献标志码:
A
摘要:
摘 要 目的：分析盐酸帕罗西汀片联合养阴益气中药对糖尿病合并抑郁症患者SDS、DQOL及TESS评分影响。方法：选择80例糖尿病合并抑郁症患者进行研究，根据治疗方法的不同，均分为观察组和对照组。对照组采用盐酸帕罗西汀片治疗，观察组患者在此基础上联合养阴益气中药进行治疗。观察两组患者治疗后血糖情况、SDS、DQOL及TESS评分。结果：治疗后，观察组HbAlc、FBG、2hPBG明显低于对照组，有统计学意义（P＜0.05）。治疗后，观察组SDS评分、DQOL总分明显低于对照组，治疗2周后和治疗4周后的TESS评分均明显低于对照组，有统计学意义（P＜0.05）。结论： 盐酸帕罗西汀片联合养阴益气中药治疗糖尿病合并抑郁症，可控制血糖水平，改善抑郁症状，提高生活质量，不良反应小。
Abstract:
Abstract Objective: To investigate the effect of paroxetine hydrochloride tablets combined with Yangyin Yiqi TCM on SDS，DQOL and TESS score in pati were ents with diabetes complicated with depression. Methods:A study of 80 patients with diabetes mellitus complicated with depression.According to different treatment methods，they were equally divided into observation group and control group.The control group was treated with paroxetine hydrochloride tablets，while the observation group was treated with Yangyin Yiqi TCM.The blood glucose，SDS，DQOL and TESS scores of the two groups after treatment were observed.Results:After treatment，the HbAlc，FBG and 2hPBG in the observation group were significantly lower than those in the control group，with statistical significance (P＜0.05).After treatment，the SDS score and DQOL total score of the observation group were significantly lower than those of the control group，and the TESS score after 2 weeks and 4 weeks of treatment were significantly lower than those of the control group (P＜0.05).Conclusion:Paroxetine hydrochloride tablets combined with Yangyin Yiqi TCM in the treatment of diabetes mellitus with depression，can control blood sugar levels，improve depressive symptoms，improve the quality of life，less adverse reactions，can be widely used in clinical.

参考文献/References:

[1] 魏 凌. 糖尿病患者伴抑郁症临床分析 [J]. 中国实用神经疾病杂志,2016,19(15):133-134.
[2] Ostrovskaya RU，Yagubova SS，Gudasheva TA.Low-molecular-weight NGF mimetic corrects the cognitive deficit and depression-like behavior in experimental diabetes [J].Acta Naturae,2017,9(2):94-102.
[3] 谢 坤,张晓庆. 住院2型糖尿病合并抑郁症患者生命质量的相关性研究 [J]. 中华疾病控制杂志,2014,18(6):515-517.
[4] 赵 晶,娄培安,陈培培,等. 2型糖尿病合并老年痴呆的患病现况及影响因素 [J]. 中国老年学杂志,2015,35(10):2796-2798.
[5] 李 娜,刘 群,李晓娟，等.逍遥散对2型糖尿病兼抑郁症模型大鼠的作用效果 [J]. 中华中医药杂志,2015,30(6):1948-1952.
[6] 周 娟,王 牮,张 红，等. 帕罗西汀对老年糖尿病合并抑郁症患者抑郁情绪及血清炎症因子的影响 [J]. 中国老年学杂志,2015,35(15):4235-4237.
[7] 边红艳,刘 霞,韩继明，等. 2型糖尿病患者伴发抑郁症与不伴发抑郁症对比研究 [J]. 西北大学学报：自然科学版,2015,45(4):599-601.
[8] Proudfoot J，Clarke J，Gunn J.A Web-based public health intervention to reduce functional impairment and depressivesymptoms in adults with type 2 diabetes (The SpringboarD Trial): Randomized Controlled Trial Protocol [J].JMIR Res Protoc， 2017,6(8):e145.
[9] 蔺晓源,韩远山,孟 盼，等.糖尿病并发抑郁症“虚、瘀、郁”的中医病机探讨 [J]. 时珍国医国药,2016,27(8):1942-1943.
[10] Saghaei M，Omidi P，Dehkordi EH.The effectiveness of cognitive-function stress management training in glycemic control in children and in mental health of mother caring for child with type 1 diabetes mellitus [J].Diabetes Metab Syndr，2017：1871-4021.
[11] 徐 锋,刘 蓉,曾 南. 逍遥散及其衍生方治疗糖尿病及伴抑郁症的研究现状 [J]. 中药药理与临床,2016,32(1):219-223.
[12] 宋 薇,温建炫,冯惠燕，等.盐酸帕罗西汀片联合中药治疗糖尿病合并抑郁症的效果 [J]. 广东医学,2016,37(19):2967-2969.
[13] 柳 冰,左 潇,许毓玲，等.舒肝解郁胶囊联合舍曲林对老年2型糖尿病伴发抑郁的有效性及安全性 [J]. 中国实用神经疾病杂志,2016,19(13):77-78.
[14] 曹 雯,彭智远,喻 嵘，等.中医药治疗糖尿病并发抑郁症随机对照临床试验的Meta分析 [J]. 中华中医药学刊,2017,36(8):2016-2019.
[15] 张韦华,冯兴中. 糖尿病合并抑郁症的中医药治疗概况 [J]. 中华中医药杂志,2016,31(4):1374-1376.

相似文献/References:

[1]罗荔.降糖饮联合西药治疗儿童1型糖尿病44例[J].陕西中医杂志,2016,(10):1299.
[2]单亮亮,邓小敏,王振刚,等.五味消渴方治疗糖尿病机理探析[J].陕西中医杂志,2017,(06):783.
[3]王巍,赵平.参芪麦味地黄汤联合运动疗法对妊娠期糖尿病气阴两虚型患者 糖脂代谢及妊娠结局的影响*[J].陕西中医杂志,2018,(10):1339.
[4]王颖.益气降糖饮联合胰岛素对妊娠期糖尿病孕妇血糖、 内脂素水平及妊娠结局的影响*[J].陕西中医杂志,2018,(10):1342.
　Wang Ying..Effects of Yiqi Jiangtang decoction combined with insulin on blood glucose， visfatin level and pregnancy outcome in patients with gestational diabetes mellitus[J].,2018,(5):1342.
[5]张 新.益气养血汤联合痔炎冲洗灵治疗肛周脓肿合并糖尿病患者切开〖JZ〗对口引流挂线术后创面愈合的影响[J].陕西中医杂志,2019,(3):368.
[6]刘 静,周娅妮,周晓玲,等.柴胡加龙骨牡蛎汤联合针刺治疗青少年抑郁症疗效〖JZ〗及对患者血清尿酸影响的研究*[J].陕西中医杂志,2019,(3):387.
[7]高咏莉.疏肝活血养心方治疗抑郁症临床效果及安全性研究*[J].陕西中医杂志,2019,(1):40.
　GAO Yongli..Clinical study on the effect and safety of Shugan Huoxue Yangxin decoction in treating depression[J].,2019,(5):40.
[8]刘 辉,王连伟,乔 飞,等.知柏地黄汤联合个体化营养支持治疗糖尿病合并肺结核疗效及对患者T淋巴细胞亚群的影响*[J].陕西中医杂志,2019,(1):76.
[9]杨 敏,姜钧文,肖 蕾.中医体质与急性心肌梗死及其危险因素的相关性研究*[J].陕西中医杂志,2019,(4):437.
　YANG Min,JIANG Junwen,XIAO Lei..Study on the correlation between constitution of traditional Chinese medicine and acute myocardial infarction and its risk factors[J].,2019,(5):437.
[10]秦福芳,阎 磊,申凤娟,等.血必净注射液治疗老年糖尿病合并急性肾盂肾炎疗效研究[J].陕西中医杂志,2019,(4):456.
　QIN Fufang,SHEN Fengjuan,SHAO Fengmin..Effect of Xuebijing injection on acute pyelonephritis in elderly patients with diabetes[J].,2019,(5):456.

备注/Memo

备注/Memo:
*河南省教育厅自然科学基金项目(2010A360029)
更新日期/Last Update: 2019-05-07