[1]李佳凝,李佳露,谢钰然.桑叶防治糖尿病的活性成分及其作用机制研究进展[J].陕西中医,2025,46(10):1425-1428.[doi:DOI:10.3969/j.issn.1000-7369.2025.10.025]
 LI Jianing,LI Jialu,XIE Yuran.Research progress on bioactive components and their action mechanisms of Mori Folium for prevention and treatment of diabetes[J].,2025,46(10):1425-1428.[doi:DOI:10.3969/j.issn.1000-7369.2025.10.025]
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桑叶防治糖尿病的活性成分及其作用机制研究进展

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年10期
页码:
1425-1428
栏目:
综 述
出版日期:
2025-10-05

文章信息/Info

Title:
Research progress on bioactive components and their action mechanisms of Mori Folium for prevention and treatment of diabetes
作者:
李佳凝李佳露谢钰然
(南方医科大学中医药学院,广东 广州 510515)
Author(s):
LI JianingLI JialuXIE Yuran
(School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China)
关键词:
桑叶糖尿病生物碱黄酮多糖
Keywords:
Mori foliumDiabetesAlkaloidFlavonoidPolysaccharide
分类号:
R 282
DOI:
DOI:10.3969/j.issn.1000-7369.2025.10.025
文献标志码:
A
摘要:
桑叶作为传统中药,其降血糖活性成分及作用机制研究取得显著进展。在前期文献报道基础上,本文综述了桑叶提取物中治疗糖尿病的活性成分及其作用机制,其中以生物碱类、黄酮类和多糖类为要,其发挥降血糖的作用机制呈现多成分、多靶点、多途径的特征。目前研究已发现桑叶中的生物碱类、黄酮类及多糖类主要可通过:抑制α-葡萄糖苷酶减少葡萄糖吸收;糖代谢通路调节;胰岛素分泌与信号调控;激活单磷酸腺苷激活的蛋白激酶(AMPK)信号通路;抗氧化应激作用;肠道吸收干预;机制整合与协同效应等发挥降低血糖的作用。本文通过综述讨论桑叶防治糖尿病活性成分及其作用机制研究进展,以期为桑叶治疗糖尿病的研究提供依据和参考。
Abstract:
As a traditional Chinese medicine,mulberry leaf has seen remarkable progress in research on its hypoglycemic active components and their mechanisms of action.Building upon previous literature reports,this paper reviews the active components in mulberry leaf extracts that are effective in treating diabetes,with a focus on alkaloids,flavonoids,and polysaccharides.The hypoglycemic mechanisms of these components exhibit characteristics of multi-component,multi-target,and multi-pathway actions.Current research has revealed that the alkaloids,flavonoids,and polysaccharides in mulberry leaves primarily lower blood glucose through the following mechanisms:inhibiting α-glucosidase to reduce glucose absorption;regulating glucose metabolism pathways;modulating insulin secretion and signaling;activating the Adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway;exerting antioxidant stress effects;intervening in intestinal absorption and achieving mechanism integration and synergistic effects.By reviewing and discussing the research progress on the active components and mechanisms of mulberry leaf in preventing and treating diabetes,this paper aims to provide a basis and reference for further studies on mulberry leaf’s therapeutic potential in diabetes.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目(82474085);陕西省重点研发计划项目(2022SF-301);南方医科大学大学生创新训练项目(202312121386)
更新日期/Last Update: 2025-10-10