[1]高咏莉.疏肝活血养心方治疗抑郁症临床效果及安全性研究*[J].陕西中医,2019,(1):40-42.
　GAO Yongli..Clinical study on the effect and safety of Shugan Huoxue Yangxin decoction in treating depression[J].,2019,(1):40-42.
点击复制

疏肝活血养心方治疗抑郁症临床效果及安全性研究*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年1期
页码:
40-42
栏目:
临床研究
出版日期:
2019-01-05

文章信息/Info

Title:
Clinical study on the effect and safety of Shugan Huoxue Yangxin decoction in treating depression
文章编号:
DOI:10.3969/j.issn.10007369.2019.01.012
作者:
高咏莉
郑州市第八人民医院精神科（郑州453000）
Author(s):
GAO Yongli.
Department of Psychiatry, 8th people’s Hospital of Zhengzhou（Zhengzhou 453000）
关键词:
疏肝活血养心方; 抑郁症; 安全性; 汉密尔顿抑郁量表; 疗效; 不良反应
Keywords:
Key words Shugan Huoxue Yangxin decoction; Depression; Safety; Hamilton depression scale; Clinical; Adverse reaction
分类号:
R749.41
文献标志码:
A
摘要:
摘 要 目的 ：探讨分析疏肝活血养心方在抑郁症患者中的临床应用效果，及治疗方案的安全性分析。方法： 将143例抑郁症患者纳为研究对象，所有患者符合抑郁症诊断标准且自愿参与研究，告知患者本次研究方案，依照其治疗意愿进行分组，对照组70例患者采用常规西药治疗，观察组73例患者则给予疏肝活血养心方治疗，分析两组患者的临床疗效及治疗安全性，观察不同时段患者的汉密尔顿抑郁量表（HAMD）的变化情况。结果：经过2个月的治疗，两组患者均有改善，但观察组治疗效果明显优于对照组，且观察组不良反应的发生率更低，组间比较结果有统计学意义（P<0.05）；治疗前与治疗后1月两组患者HAMD评分差异不明显，但治疗后2月组间评分差异较大，观察组明显低于对照组（P<0.05）。结论：常规西药治疗抑郁症有一定的疗效，但会发生较多不良反应，同时对于患者的抑郁改善效果并不稳定，中药方剂不但降低了不良反应的发生率，同时对于抑郁患者的症状改善更加显著，疏肝活血养心方治疗抑郁症安全有效。
Abstract:
Abstract Objective ：To explore the clinical application of Shugan Huoxue Yangxin decoction in patients with depression and analyze the safety of the treatment plan. Methods: 143 depression patients diagnosed met the diagnostic criteria for depression and voluntarily participated in the study. The patients were informed of the study protocol and grouped according to their willingness to treat. 70 patients in the control group received conventional western medicine. 73 patients in the discussion group were treated with Shugan Huoxue Yangxin decoction. The clinical efficacy and safety of the two groups of patients were analyzed, and the changes of Hamilton depression Scale (HAMD) were observed at different time points. Results:After 2 months of treatment, both groups of patients improved, but the treatment effect of the discussion group was significantly better than that of the control group, and the incidence of adverse reactions in the discussion group was even lower. The comparison between the two groups was statistically significant (P<0.05). There was no significant difference in HAMD scores between the two groups before and after the treatment, but there was a significant difference between the two groups after treatment. The discussion group was significantly lower than the control group (P<0.05). Conclusions： Conventional western medicine has certain curative effect in the treatment of depression, but it has many adverse reactions. At the same time, the improvement effect of depression on the patient is not stable. Chinese herbal formula not only reduces the incidence of adverse reactions, but also improves the symptoms of depression patients. Shugan Huoxue Yangxin decoction is safe and effective for the treatment of depression.

参考文献/References:

[1] 郭新文, 王 隽, 阿不力克·木克里木,等. 疏肝解郁胶囊联合文拉法辛治疗抑郁症合并功能性消化不良的临床疗效和安全性研究[J] . 中国现代医学杂志, 2016, 26(20):133136.
[2] 陈顺革, 刘秀娥, 张淑艳,等. 养心汤加减联合盐酸舍曲林片治疗抑郁症的临床效果[J] . 陕西中医, 2016, 37(6):676677.
[3] 郭彩娥, 张玉英, 乔泽国,等. 疏肝解郁胶囊联合草酸艾司西酞普兰治疗中风后抑郁症的临床疗效及其安全性[J] . 临床合理用药杂志, 2017, 10(27):12.
[4] 刘 义, 冯 慧, 刘文娟,等. 疏肝养心针刺法联合文拉法辛对抑郁障碍残留症状及单胺类神经递质水平的影响[J] . 中华全科医学, 2017, 15(8):13781381.
[5] 陈顺革, 刘秀娥, 张淑艳,等. 草酸艾司西酞普兰片联合养心汤加减治疗抑郁症的疗效及安全性[J] . 神经疾病与精神卫生, 2016, 16(2):173175.
[6] 牛永利, 赵俊龙, 李红阁. 针刺联合中药治疗肝气郁结型抑郁症的临床观察[J] . 陕西中医, 2016, 37(10):14061407.
[7] 陈素珍, 王世强, 胡丹丹,等. 慢性阻塞性肺疾病合并抑郁症患者中医体质特点分析[J] . 中华全科医学, 2017, 15(3):505507.
[8] 李 娟. 滋肾疏肝中药治疗更年期抑郁症疗效及对5羟色胺、色氨酸羟化酶2的影响[J] . 现代中西医结合杂志, 2017, 26(17):18951897.
[9] 袁清洁, 郭建友, 王建伟,等. 基于皮质酮炎性反应线粒体网络研究抑郁症肝郁脾虚病机及醒脾解郁方干预效应[J] . 中华中医药杂志, 2017, 32(5):22412245.〖ZK)〗
[10] 沈捷雯, 董 莉, 黄宏丽. 补肾解郁清心方结合针刺对围绝经期抑郁症患者ACTINHFS通路的影响[J] . 现代中西医结合杂志, 2017, 26(23):25122514.
[11] 郭利红, 姚华强, 王 芳. 清心解郁汤治疗围绝经期综合征抑郁症的临床观察[J] . 陕西中医, 2016, 37(9):12031204.
[12] 张志英, 郭素芹. 中药辅助氟西汀治疗脑卒中后抑郁的疗效及对药物依赖性的影响[J] . 中国临床研究, 2016, 29(5):613616.

相似文献/References:

[1]刘 静,周娅妮,周晓玲,等.柴胡加龙骨牡蛎汤联合针刺治疗青少年抑郁症疗效〖JZ〗及对患者血清尿酸影响的研究*[J].陕西中医,2019,(3):387.
[2]刘 娟,田 磊,赵 杨,等.电针对慢性应激抑郁模型大鼠脑组织内大麻素水解酶的影响[J].陕西中医,2019,(5):553.
[3]何 丽,朱亚丽,罗 方,等.盐酸帕罗西汀片联合养阴益气中药治疗糖尿病合并抑郁症 疗效研究*[J].陕西中医,2019,(5):645.
　HE Li,ZHU Yali,LUO Fang,et al.Effects of paroxetine hydrochloride tablets combined with Yangyin Yiqi TCM on SDS，DQOL and TESS score in diabetic patients with depression[J].,2019,(1):645.
[4]梁 玉,李艳芳,王小波.逍遥散联合重复经颅磁刺激治疗肝郁脾虚型抑郁症疗效及对患者血清FGF-22、BDNF水平的影响[J].陕西中医,2021,(1):33.[doi:DOI:10.3969/j.issn.1000-7369.2020.01.007]
　LIANG Yu,LI Yanfang,WANG Xiaobo.Efficacy of Xiaoyao powder combined with repeated transcranial magnetic stimulation in the treatment of depression of liver depression and spleen deficiency and its effect on serum FGF-22 and BDNF levels[J].,2021,(1):33.[doi:DOI:10.3969/j.issn.1000-7369.2020.01.007]
[5]薛茜尹,梅 妍.心舒一号方结合度洛西汀治疗抑郁症临床研究[J].陕西中医,2022,(1):49.[doi:DOI:10.3969/j.issn.1000-7369.2022.01.011]
[6]袁 芳,李 彬,王少松,等.升降出入辨证思维在针灸治疗抑郁症中的应用探讨[J].陕西中医,2022,(2):215.[doi:DOI:10.3969/j.issn.1000-7369.2022.02.018]
　YUAN Fang,LI Bin,WANG Shaosong,et al.Application of dialectical thinking on the theory of qi movement ascending and descending in acupuncture treatment of depressive disorder[J].,2022,(1):215.[doi:DOI:10.3969/j.issn.1000-7369.2022.02.018]
[7]田丹丹,杨 阳.电针调控CASP-1/GSDMD细胞焦亡信号通路对抑郁症小鼠干预机制[J].陕西中医,2022,(7):851.[doi:DOI:10.3969/j.issn.1000-7369.2022.07.008]
　TIAN Dandan,YANG Yang.The intervention mechanism of electroacupuncture on CASP-1/GSDMD pyroptosis signaling pathway in depressed mice[J].,2022,(1):851.[doi:DOI:10.3969/j.issn.1000-7369.2022.07.008]
[8]吴 楠,王 渊,王 强,等.针刺耳迷走神经治疗抑郁症研究进展[J].陕西中医,2022,(8):1140.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.036]
　WU Nan,WANG Yuan,WANG Qiang,et al.Progress on the treatment of depressive disorder by acupuncture auricular vagus nerve[J].,2022,(1):1140.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.036]
[9]冯婿洋,王秋烜,韩景献,等.针灸治疗抑郁症作用机制研究进展[J].陕西中医,2024,(4):566.[doi:DOI:10.3969/j.issn.1000-7369.2024.04.030]
　FENG Xuyang,WANG Qiuxuan,HAN Jingxian,et al.Progress in the study of the mechanism of acupuncture in the treatment of depression[J].,2024,(1):566.[doi:DOI:10.3969/j.issn.1000-7369.2024.04.030]
[10]徐 欣,高丽丽,李文萍.电针对肝郁脾虚型抑郁症大鼠HMGB1/RAGE/TLR4通路及小胶质细胞活化的影响[J].陕西中医,2024,(11):1471.[doi:DOI:10.3969/j.issn.1000-7369.2024.11.006]
　XU Xin,GAO Lili,LI Wenping.Impacts of electroacupuncture on HMGB1/RAGE/TLR4 pathway and microglia activation in rats with liver depression and spleen deficiency type of depression[J].,2024,(1):1471.[doi:DOI:10.3969/j.issn.1000-7369.2024.11.006]

备注/Memo

备注/Memo:
*河南省卫生和计划生育委员会临床研究项目（17000521）
更新日期/Last Update: 2019-03-13