[1]冯婿洋,王秋烜,韩景献,等.针灸治疗抑郁症作用机制研究进展[J].陕西中医杂志,2024,(4):566-569.[doi:DOI:10.3969/j.issn.1000-7369.2024.04.030]
 FENG Xuyang,WANG Qiuxuan,HAN Jingxian,et al.Progress in the study of the mechanism of acupuncture in the treatment of depression[J].,2024,(4):566-569.[doi:DOI:10.3969/j.issn.1000-7369.2024.04.030]
点击复制

针灸治疗抑郁症作用机制研究进展
分享到:

《陕西中医》杂志[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年4期
页码:
566-569
栏目:
综 述
出版日期:
2024-04-05

文章信息/Info

Title:
Progress in the study of the mechanism of acupuncture in the treatment of depression
作者:
冯婿洋王秋烜韩景献张雪竹
(1.天津中医药大学第一附属医院 国家中医针灸临床医学研究中心,天津 300193; 2.天津中医药大学,天津 301617)
Author(s):
FENG XuyangWANG QiuxuanHAN JingxianZHANG Xuezhu
(First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)
关键词:
抑郁症 针灸 电针 线粒体稳态 细胞焦亡 神经周围网
Keywords:
Depression Acupuncture Electroacupuncture Mitochondrial homeostasis Cell pyroptosis Perineural network
分类号:
R 749.4
DOI:
DOI:10.3969/j.issn.1000-7369.2024.04.030
文献标志码:
A
摘要:
抑郁症是一种常见的精神疾病,临床表现为情绪低落,兴趣减退,甚则产生自杀倾向,危害机体健康。针灸是治疗抑郁症的较好方法,对其症状具有良好的改善作用。但目前尚缺乏针灸治疗抑郁症作用机制的归纳性文献。因此,从针灸对抑郁症神经递质及其受体、神经内分泌、脑肠轴、炎性细胞因子的影响,以及线粒体稳态、神经周围网、细胞焦亡、氧化应激等方面的调控作用入手,详细地对针刺治疗抑郁症的机制进行归纳和探讨。
Abstract:
Depression(DEP)is a common mental illness,clinically manifested as depressed mood,loss of interest,or even suicidal tendencies,which jeopardizes the health of the organism.Acupuncture is a good treatment for DEP,which can improve the symptoms.However,there is a lack of generalized literature on the mechanism of action of acupuncture in the treatment of DEP.Therefore,this paper summarizes and discusses the mechanism of acupuncture treatment of DEP in terms of the effects of acupuncture on DEP neurotransmitters and their receptors,neuroendocrine,brain-gut axis,and inflammatory cytokines,as well as in the regulation of mitochondrial homeostasis,perineural network,cellular pyrokinesis,and oxidative stress.

参考文献/References:

[1] CUI R.Editorial:A systematic review of depression[J].Curr Neuropharmacol,2015,13(4):480.
[2] 李娟,钱炜,IQBAL M A.耳鸣与焦虑抑郁相关性及治疗研究进展[J].陕西医学杂志,2023,52(12):1775-1777,1781.
[3] 杨潇,董再全,王瑜,等.抑郁症病因学和治疗学的研究进展[J].中国科学:生命科学,2022,52(11):1678-1691.
[4] SCHILDKRAUT J J,DRASKOCZY P R,GERSHON E S,et al.Catecholamine metabolism in affective disorders.Ⅳ.Preliminary studies of norepinephrine metabolism in depressed patients treated with amitriptyline[J].Journal of Psychiatric Research,1972,9(3):173-185.
[5] 黄凯旋,米健国,李文忠.越鞠保和丸联合温针灸治疗抑郁症临床观察[J].山西中医,2021,37(11):18-21.
[6] 申鹏飞,孔莉,石学敏.醒脑开窍针法治疗卒中后抑郁症临床研究[J].中国针灸,2005(1):15-17.
[7] 孙培养,蔡荣林,李佩芳,等.“通督调神”针刺对脑卒中后抑郁大鼠海马神经元保护作用及单胺类神经递质的影响[J].中国针灸,2019,39(7):741-747.
[8] LI P,HUANG W,YAN Y N,et al.Acupuncture can play an antidepressant role by regulating the intestinal microbes and neurotransmitters in a rat model of depression[J].Medical Science Monitor,2021,27:e929027.
[9] 陈欣怡,李永丰,徐晨曦,等.针刺干预抑郁症在中枢5-羟色胺系统的效应机制研究进展[J].中华中医药学刊,2022,40(7):150-154.
[10] 廖继武,王丝丝,杨海华,等.抑郁症患者的血清谷氨酸及γ-氨基丁酸系统水平[J].中国心理卫生杂志,2020,34(2):87-91.
[11] 阎路达,周鹏,赖美琪,等.针刺联合低频rTMS治疗轻中度抑郁障碍共病失眠:随机对照试验[J].中国针灸,2023,43(4):374-378,400.
[12] 叶小芳.疏肝健脾汤联合针刺治疗抑郁症患儿疗效观察及对神经递质的影响[J].新中医,2020,52(22):117-119.
[13] 肖伟,章显宝,王震,等.针刺对卒中后抑郁大鼠行为学及海马区神经递质的影响[J].上海针灸杂志,2017,36(6):751-756.
[14] 周海腾,潘俊夫.高龄产妇血浆神经肽Y和P物质表达与产后抑郁的相关性[J].中国妇幼保健,2022,37(16):2921-2924.
[15] SHARMA A,REN X,ZHANG H,et al.Effect of depression and suicidal behavior on neuropeptide Y(NPY)and its receptors in the adult human brain:A postmortem study[J].Progress in Neuro-Psychopharmacology & Biological Psychiatry,2022(112):110428.
[16] 王璇,史福平,路保慧,等.针灸辅助治疗脑卒中后抑郁患者后遗症对患者神经功能及日常生活能力的影响[J].河北医药,2022,44(12):1865-1868.
[17] 刘雯雯,缪花,孙义,等.针刺联合重复经颅磁刺激技术治疗对高龄产后抑郁症患者抑郁程度、睡眠质量及血浆神经肽水平的影响[J].检验医学与临床,2023,20(10):1440-1442,1446.
[18] LEE B,SHIM I,LEE H J,et al.Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats[J].Neuroscience Letters,2009,453(3):151-156.
[19] UNDERWOOD M D,GALFALVY H,HSIUNG S C,et al.A stress protein-based suicide prediction score and relationship to reported early-life adversity and recent life stress[J].Int J Neuropsychopharmacol,2023,26(7):501-512.
[20] 李佳豪,王建云,李静兰,等.针刺对抑郁大鼠海马FKBPs/GR/BDNF信号通路相关因子表达的影响[J].环球中医药,2023,16(8):1487-1493.
[21] 袁权,诸毅晖,裴钰,等.针刺对下丘脑-垂体-肾上腺轴的调整作用[J].时珍国医国药,2012,23(7):1795-1797.
[22] 李亚欢,梁星辰,姜会梨,等.SP600125阻断JNK信号通路下电针对慢性不可预知性温和应激大鼠HPA轴的影响[J].针灸临床杂志,2019,35(9):62-67,101.
[23] 张倩,付建军.干扰素和直接作用抗病毒药物治疗慢性丙型肝炎所致抑郁症发病机制研究进展[J].陕西医学杂志,2022,51(6):760-763.
[24] 赵季宇,闫婧,王红阳,等.麦粒灸对甲状腺功能减退症伴抑郁状态大鼠血清5-HT、皮质醇及海马MR、GR表达的影响[J].中国针灸,2022,42(5):525-532.
[25] 何其洋,陈敏,龙文玲.基于脑肠轴学说探讨溃疡性结肠炎中医情志发病机制[J].世界最新医学信息文摘,2019,19(82):112-113.
[26] 魏思维,张景明,李影琳芝,等.基于“致中和”探析从脾胃论治抑郁症的机制[J].陕西中医,2023,44(9):1269-1272.
[27] 张旭龙,范晓艳,王明威,等.基于“脑-肠轴”理论探讨“醒脑调枢”针刺治疗抑郁症[J].四川中医,2022,40(8):32-35.
[28] 金树英,户丽,包伍叶,等.针刺对慢性应激抑郁大鼠血清和脑炎性细胞因子的影响[J].针灸临床杂志,2014,30(5):57-60.
[29] 孙华,赵慧,张捷,等.针刺百会、足三里对抑郁症患者血清炎性细胞因子水平的影响[J].中国针灸,2010,30(3):195-199.
[30] GUO W,TANG Z,CAI Z,et al.Iptakalim alleviates synaptic damages via targeting mitochondrial ATP:Ensitive potassium channel in depression[J].The FASEB Journal,2021,35(5):e21581.
[31] 邱雪,赵雯婧,王飞燕,等.粉防己碱调节Nrf2/HO-1/NLRP3信号通路对抑郁症大鼠神经元损伤的影响[J].疑难病杂志,2023,22(6):646-652.
[32] CHENG W J,LI P,HUANG W Y,et al.Acupuncture relieves stress-induced depressive behavior by reducing oxidative stress and neuroapoptosis in rats[J].Frontiers in Behavioral Neuroscience,2021,15:783056.
[33] ZHANG Y,GUO Z,YANG L,et al.Possible involvement of perineuronal nets in anti-depressant effects of electroacupuncture in chronic-stress-induced depression in rats[J].Neurochem Res,2023,48(10):3146-3159.
[34] 贾春凯,王韬,王荔.细胞焦亡在卒中及抑郁症中的研究进展[J].中风与神经疾病杂志,2023,40(5):463-467.
[35] 田丹丹,杨阳.电针调控CASP-1/GSDMD细胞焦亡信号通路对抑郁症小鼠干预机制[J].陕西中医,2022,43(7):851-856.
[36] 樊凌,吕爱平,符文彬,等.针刺对抑郁症大鼠海马5-HT、NE、BDNF水平和神经元细胞凋亡相关基因表达的影响[J].中华中医药杂志,2016,31(8):3204-3207.
[37] 吴红芳,金齐颖,张园园,等.星形胶质细胞与抑郁症相关研究进展[J].华北理工大学学报(医学版),2018,20(5):409-415.

相似文献/References:

[1]刘 静,周娅妮,周晓玲,等.柴胡加龙骨牡蛎汤联合针刺治疗青少年抑郁症疗效〖JZ〗及对患者血清尿酸影响的研究*[J].陕西中医杂志,2019,(3):387.
[2]高咏莉.疏肝活血养心方治疗抑郁症临床效果及安全性研究*[J].陕西中医杂志,2019,(1):40.
 GAO Yongli..Clinical study on the effect and safety of Shugan Huoxue Yangxin decoction in treating depression[J].,2019,(4):40.
[3]刘 娟,田 磊,赵 杨,等.电针对慢性应激抑郁模型大鼠脑组织内大麻素水解酶的影响[J].陕西中医杂志,2019,(5):553.
[4]何 丽,朱亚丽,罗 方,等.盐酸帕罗西汀片联合养阴益气中药治疗糖尿病合并抑郁症 疗效研究*[J].陕西中医杂志,2019,(5):645.
 HE Li,ZHU Yali,LUO Fang,et al.Effects of paroxetine hydrochloride tablets combined with Yangyin Yiqi TCM on SDS,DQOL and TESS score in diabetic patients with depression[J].,2019,(4):645.
[5]樊海元,林砚铭,巫 斌△.川芎茶调散合身痛逐瘀汤加减配合针灸治疗坐骨神经痛疗效研究*[J].陕西中医杂志,2020,(2):206.
 FAN Haiyuan,LIN Yanming,WU Bin..Curative effect of Chuanxiong Chatiaosan and Modified Shengtong Zhuyu decoction combined with acupuncture on sciatica[J].,2020,(4):206.
[6]李 媛,赵正恩,张少军,等.针灸结合咽部冰刺激训练治疗脑卒中后吞咽障碍临床研究*[J].陕西中医杂志,2020,(2):238.
 LI Yuan,ZHAO Zhengen,ZHANG Shaojun,et al.Clinical study on the treatment of dysphagia after stroke with acupuncture combined with pharyngeal ice stimulation[J].,2020,(4):238.
[7]吴 婧,张 胜.清瘟扶正饮联合针灸防治新型冠状病毒肺炎的思考[J].陕西中医杂志,2020,(3):290.
[8]时文才,聂晨旭,胡晓龙,等.黄芪桂枝五物汤合血府逐瘀汤联合针灸治疗早期强直性脊柱炎临床研究*[J].陕西中医杂志,2020,(3):315.
[9]张凤平.针灸联合闪罐治疗特发性面神经麻痹疗效研究[J].陕西中医杂志,2020,(3):380.
[10]李晨辉,吴永平,谢 芳,等.耳穴贴压联合针灸辅助激素治疗月经不调临床研究*[J].陕西中医杂志,2020,(3):387.
 LI Chenhui,WU Yongping,XIE Fang,et al.Clinical efficacy of auricular point sticking combined with acupuncture and moxibustion assisted with hormones on irregular menstruation[J].,2020,(4):387.
[11]袁 芳,李 彬,王少松,等.升降出入辨证思维在针灸治疗抑郁症中的应用探讨[J].陕西中医杂志,2022,(2):215.[doi:DOI:10.3969/j.issn.1000-7369.2022.02.018]
 YUAN Fang,LI Bin,WANG Shaosong,et al.Application of dialectical thinking on the theory of qi movement ascending and descending in acupuncture treatment of depressive disorder[J].,2022,(4):215.[doi:DOI:10.3969/j.issn.1000-7369.2022.02.018]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(30630074,82174492); 天津市重点研发计划项目(20YFZCSY00810)
更新日期/Last Update: 2024-04-10