[1]徐雯珺,华文进,陈 慧,等.滋水清肝饮加减联合二冬汤加减对糖尿病合并甲状腺功能亢进症患者内分泌代谢的影响[J].陕西中医,2022,(6):736-739.[doi:DOI:10.3969/j.issn.1000-7369.2022.06.014]
　XU Wenjun,HUA Wenjin,CHEN Hui,et al.Effects of Zishui Qinggan decoction combined with Erdong decoction on endocrine and metabolism of diabetic patients with hyperthyroidism[J].,2022,(6):736-739.[doi:DOI:10.3969/j.issn.1000-7369.2022.06.014]
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滋水清肝饮加减联合二冬汤加减对糖尿病合并甲状腺功能亢进症患者内分泌代谢的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年6期
页码:
736-739
栏目:
临床研究
出版日期:
2022-06-05

文章信息/Info

Title:
Effects of Zishui Qinggan decoction combined with Erdong decoction on endocrine and metabolism of diabetic patients with hyperthyroidism
作者:
徐雯珺; 华文进; 陈 慧; 张 亮
(江南大学附属医院内分泌科,江苏 无锡 214122)
Author(s):
XU Wenjun; HUA Wenjin; CHEN Hui; ZHANG Liang
(Department of Endocrinology,Affiliated Hospital of Jiangnan University,Wuxi 214122,China)
关键词:
糖尿病;  甲状腺功能亢进症;  滋水清肝饮;  二冬汤;  甲状腺功能;  内分泌代谢
Keywords:
Diabetes;  Hyperthyroidism;  Zishui Qinggan decoction;  Erdong decoction;  Thyroid function;  Endocrine metabolism
分类号:
R 587.1
DOI:
DOI:10.3969/j.issn.1000-7369.2022.06.014
文献标志码:
A
摘要:
目的:探究滋水清肝饮联合二冬汤加减治疗糖尿病(DM)合并甲状腺功能亢进症的临床疗效及对内分泌代谢的影响。方法:选取120例糖尿病合并甲状腺功能亢进症患者,按照随机数字表法分为常规组、研究组,每组各60例。常规组予二冬汤加减治疗,研究组在常规组基础上予滋水清肝饮加减。比较两组患者的临床疗效、甲状腺功能、糖代谢指标以及不良反应; Pearson相关性分析甲状腺功能与糖代谢指标的相关性。结果:研究组临床总有效率高于对照组,差异有统计学意义(P<0.01)。与治疗前比较,治疗后两组患者FPG、2 hPG水平均降低,且研究组FPG、2 hPG水平低于常规组,差异有统计学意义(均P<0.01)。与治疗前比较,治疗后两组患者FT4、TT4、T4水平均降低,且研究组T4、FT4、TT4水平均低于常规组,差异有统计学意义(均P<0.01)。两组并发症发生率比较,差异无统计学意义(χ2=0.70,P>0.05)。2 hPG与T4、FT4、TT4,FPG与T4、FT4、TT4均呈正相关。结论:糖尿病合并甲状腺功能亢进症患者应用滋水清肝饮联合二冬汤加减治疗可有效改善糖代谢及甲状腺功能,提高临床疗效。
Abstract:
Objective:To explore clinical efficacy of Zishui Qinggan decoction combined with Erdong decoction in the treatment of diabetes mellitus(DM)complicated with hyperthyroidism and its influence on endocrine metabolism.Methods:120 patients with diabetes combined with hyperthyroidism were selected and divided into routine group and study group according to random number table method,with 60 cases in each group.The routine group was treated with Erdong decoction,and the study group was treated with Zishui Qinggan decoction on the routine group basis.The clinical efficacy,thyroid function,glucose metabolism index and adverse reactions of the two groups were compared,and the correlation between thyroid function and glucose metabolism index were analyzed by Pearson correlation analysis.Results:The total effective rate in the study group was higher than that in the control group,difference statistically significant(P<0.01).After treatment the levels of FPG and 2 hPG in the two groups were lower than before treatment,and the levels of FPG and 2 hPG in the study group were lower than those in the routine group,difference statistically significant(all P<0.01).Compared with before treatment,the levels of FT4,TT4 and T4 in the two groups decreased after treatment,and the levels of T4,FT4 and TT4 in the study group were lower than those in the routine group,difference statistically significant(all P<0.01).There was no significant difference in the incidence of complications between the two groups(χ2=0.70,P>0.05).2 hPG were positively correlated with T4,FT4 and TT4.FPG were positively correlated with T4,FT4 and TT4.Conclusion:Zishui Qinggan decoction combined with Erdong decoction can effectively improve glucose metabolism and thyroid function in diabetic patients with hyperthyroidism,and improve clinical efficacy.

参考文献/References:

[1] 聂晓燕.中西医结合护理在2型糖尿病合并甲状腺功能亢进患者中的应用效果[J].西部中医药,2019,32(4):126-128.
[2] 黄春梅,赖冬琴,李锋进,等.2型糖尿病合并甲状腺功能亢进症患者的临床表现与治疗预后分析[J].中国医药科学,2019,9(24):261-263.
[3] 杨 芳,檀增桓,韦志坤,等.碘-131联合胰岛素泵治疗2型糖尿病伴发甲状腺功能亢进症的近远期疗效及对骨代谢指标的影响[J].现代生物医学进展,2020,20(7):1368-1372.
[4] 庞雅玲,王养维,李 辉,等.2型糖尿病合并甲状腺功能亢进症患者脂肪因子及氧化应激状态评估[J].陕西医学杂志,2016,45(7):819-821.
[5] 窦淑文,谭从娥,王相东,等.从“调畅气机”论治糖尿病胃轻瘫研究进展[J].陕西中医,2021,42(4):540-542.
[6] 鲁阳侠,孟 帆,周云蕾,等.养阴清热消瘿方联合甲巯咪唑治疗甲状腺功能亢进症疗效及对患者甲状腺素水平和骨密度影响的研究[J].陕西中医,2019,40(3):358-360.
[7] 潘竞霞,何小莲,张 瑾,等.甲状腺功能亢进症中医辨证与彩色多普勒超声影像特征的相关性研究[J].四川中医,2017,35(8):39-41.
[8] 张曼玲,张莹雯.从糖尿病肾病病机论中医药对糖尿病肾病治疗的研究进展[J].天津中医药,2017,34(9):69-73.
[9] 斯洁骊,罗 怡,李京晶.联合检测评估糖尿病合并甲状腺功能亢进症患者病情进展的价值[J].中南医学科学杂志,2019,47(4):411-413.
[10] 国家中医药管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:6.
[11] 刘红梅,施秉银.西安某三甲教学医院2型糖尿病住院患者治疗情况调查研究[J].陕西医学杂志,2018,47(4):536-539.
[12] 杨 力,赵燕莉,杨 芳,等.131I联合胰岛素泵治疗2型糖尿病并甲状腺功能亢进症的效果及预后分析[J].解放军预防医学杂志,2018,36(1):39-41.
[13] 黄晓芳,陈永华,倪洪岗,等.燥热化“毒”在消渴病病机中的作用分析[J].陕西中医,2020,41(5):106-109.
[14] 黄雯洁,沈 劼,郭 丽.中医辨治甲状腺功能亢进症研究进展[J].中国中医基础医学杂志,2018,24(11):156-158.
[15] 王宏亮,赵 媛,李桂萍.糖尿病合并甲状腺功能亢进患者血清胰岛素抵抗和脂联素表达水平及其与甲状腺激素的相关性分析[J].解放军医药杂志,2017,29(4):103-105.
[16] 袁新国,谢梦洲,杨 英,等.二冬汤和有氧运动对2型糖尿病大鼠糖代谢和脂代谢的影响[J].重庆医学,2018,47(28):12-15.
[17] 张海燕,李 燕,尹海平,等.滋水清肝饮加减方对2型糖尿病患者正性共刺激分子ICOS/ICOSL、OX40/OX40L免疫调节作用的影响[J].辽宁中医杂志,2019,46(9):1891-1895.
[18] 宋文荣.疏肝潜阳汤配合普萘洛尔治疗甲状腺功能亢进合并房颤疗效观察[J].现代中西医结合杂志,2018,27(9):969-972.
[19] 安 云.丹栀逍遥散配合胰岛素泵治疗2型糖尿病合并甲状腺功能亢进疗效观察[J].现代中西医结合杂志,2018,27(29):3254-3256.
[20] 朱 凤.丹栀逍遥散配合胰岛素泵治疗2型糖尿病合并甲状腺功能亢进疗效观察[J].现代中西医结合杂志,2017,26(32):3597-3599.

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备注/Memo

备注/Memo:
基金项目:江苏省自然科学基金资助项目(BK20191062)
更新日期/Last Update: 2022-06-09