[1]刘颖初,汪红兵,王雅欣,等.基于“补气活血”理论探讨胃癌前病变的“炎癌转化”[J].陕西中医,2023,(12):1767-1770.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.022]
　LIU Yingchu,WANG Hongbing,WANG Yaxin,et al.Discussion on “inflammatory and cancer transformation” of precancerous lesions of gastric cancer based on the theory of “invigorating qi and activating blood circulation”[J].,2023,(12):1767-1770.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.022]
点击复制

基于“补气活血”理论探讨胃癌前病变的“炎癌转化”
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年12期
页码:
1767-1770
栏目:
学术探讨
出版日期:
2023-12-05

文章信息/Info

Title:
Discussion on “inflammatory and cancer transformation” of precancerous lesions of gastric cancer based on the theory of “invigorating qi and activating blood circulation”
作者:
刘颖初1; 汪红兵2; 王雅欣2; 娄 颜2; 于金德3
(1.北京中医药大学,北京 100029; 2.北京中医医院,北京 100010; 3.北京中医医院延庆医院,北京 102199)
Author(s):
LIU Yingchu; WANG Hongbing; WANG Yaxin; LOU Yan; YU Jinde
(Beijing University of Traditional Chinese Medicine,Beijing 100029,China)
关键词:
胃癌前病变;  补气活血;  炎癌转化;  慢性胃炎;  气虚血瘀
Keywords:
Precancerous lesions of gastric cancer;  Invigorating qi and activating blood circulation;  Inflammation and cancer transformation;  Chronic gastritis;  Qi deficiency and blood stasis
分类号:
R 735.2
DOI:
DOI:10.3969/j.issn.1000-7369.2023.12.022
文献标志码:
A
摘要:
胃癌前病变(PLGC)是以胃黏膜萎缩、固有腺体减少为主要病理特征的炎性疾病,控制PLGC炎癌转化对于预防胃癌具有重要意义。PLGC包括胃黏膜萎缩、肠上皮化生及不典型增生,具有病程日久、缠绵反复的特点。纵观各医家之见解,笔者认为PLGC以脾胃气虚为本,痰凝血瘀为标。同时提出PLGC治疗应以补气活血为基本大法,既顾护脾胃之气,又祛除胃部邪气,从而达到改善胃黏膜内环境,增强机体免疫力,控制炎症向癌症转化的治疗效果。以补气活血为视角阐述PLGC炎癌转化,注重个体化差异,辨证论治,从中医学角度阐述PLGC的科学内涵,为预防及治疗胃癌提供理论依据。
Abstract:
Gastric precancerous lesion(PLGC)is an inflammatory disease characterized by atrophy of gastric mucosa and reduction of inherent glands.Controlling PLGC inflammation and cancer transformation is of great significance for preventing gastric cancer.PLGC is commonly characterized by gastric mucosal atrophy,intestinal metaplasia and atypical hyperplasia,with a long course and recurrent entanglement.Looking at the opinions of various medical experts,the author believes that PLGC is based on spleen and stomach qi deficiency,with phlegm coagulation and blood stasis as the standard.Treating on PLGC should be based on the basic principle of nourishing qi and promoting blood circulation,which not only protects the qi of spleen and stomach,but also eliminates the evil qi in the stomach,in order to improve the internal environment of gastric mucosa,enhance the body's immunity,and control the transformation of inflammation to cancer.From the perspective of invigorating qi and activating blood circulation,this article elaborates on the inflammatory and cancerous transformation of PLGC,emphasizing individual differences,differentiation of symptoms and treatment,and elaborates on the scientific connotation of PLGC from the perspective of traditional Chinese medicine,providing theoretical basis for the prevention and treatment of gastric cancer.

参考文献/References:

[1] 李军祥,陈 誩,吕 宾,等.慢性萎缩性胃炎中西医结合诊疗共识意见(2017年)[J].中国中西医结合消化杂志,2018,26(2):121-131.
[2] Blair VR,McLeod M,Carneiro F,et al.Hereditary diffuse gastric cancer:Updated clinical practice guidelines[J].Lancet Oncol,2020,21(8):e386-e397.
[3] Smyth EC,Nilsson M,Grabsch HI,et al.Gastric cancer[J].Lancet,2020,396(10251):635-648.
[4] Reuter S,Gupta SC,Chaturvedi MM,et al.Oxidative stress,inflammation,and cancer:How are they linked[J].Free Radic Biol Med,2010,49(11):1603-1616.
[5] 闫 萌,张 征,邢保健,等.胃癌组织中趋化素样因子超家族8蛋白表达与胃癌上皮-间质转化关系及临床意义[J].陕西医学杂志,2023,52(5):618-621.
[6] Pollard JW.Tumour-educated macrophages promote tumour progression and metastasis[J].Nat Rev Cancer,2004,4(1):71-78.
[7] 张忠绵,郭志玲,刘大铭,等.田德禄辨治慢性萎缩性胃炎之经验[J].江苏中医药,2022,54(9):26-29.
[8] 赵晓琳,诸葛丽,马尚清,等.252例慢性萎缩性胃炎中医证候分布规律及其病理相关性研究[J].中华中医药杂志,2022,37(12):7405-7408.
[9] 徐晶钰,张 璇,裴 蓓,等.基于NLRP3炎症小体探讨从肝胃论治胃癌前病变阻断“炎-癌”转化的重要性[J].中医药学报,2022,50(4):5-8.
[10] Kiraly O,Gong G,Olipitz W,et al.Inflammation-induced cell proliferation potentiates DNA damage-induced mutations in vivo[J].PLoS Genet,2015,11(2):1104-1109.
[11] 李朝燕,赵爱光,竹永宝,等.基于健脾法探讨中药胃肠安对晚期胃癌的影响[J].中华中医药杂志,2019,34(5):2012-2017.
[12] 刘颖初,汪红兵.李乾构运用四君子汤加减治疗慢性萎缩性胃炎经验[J].辽宁中医杂志,2022,49(5):16-19.
[13] 王雨鸽,许静茹,王俞铧,等.刘启泉教授基于“随变而调气”论治慢性萎缩性胃炎[J].陕西中医,2022,43(2):236-239.
[14] 陈伟霞,陈 彬,竹永宝,等.邱佳信教授健脾类复方胃肠安在胃癌治疗中的研究进展[J].世界中医药,2017,12(11):2864-2868.
[15] 袁嘉嘉,顾 超,孙志广,等.“炎-癌转化”的病因病机——以慢性萎缩性胃炎为例[J].长春中医药大学学报,2018,34(4):624-626.
[16] 杨 丽,郭栴子,杨小蒨,等.从“痰瘀互结”理论谈“炎-癌转化”[J].河北中医,2020,42(12):1887-1889.
[17] 杨振华,孙 波,黄傲霜,等.慢性萎缩性胃炎中医证候的胃镜及病理特征分析研究[J].中国中西医结合消化杂志,2021,29(1):58-61.
[18] 寇 媛,闻新丽,薛 峰.养胃清热化瘀汤治疗慢性萎缩性胃炎及癌前病变临床研究[J].陕西中医,2021,42(9):1233-1235.
[19] 赵 航,戴 玮.三棱莪术组方辅助治疗胃癌的临床效果研究[J].癌症进展,2019,17(8):925-928.
[20] 傅梦薇,李洪峥,王 阶.痰瘀互结证之理论与研究[J].时珍国医国药,2021,32(12):2977-2980.
[21] 施 月,李 萍,李 园,等.基于“主客交”理论探讨慢性胃炎“炎癌转化”[J].北京中医药大学学报,2021,44(10):935-939.
[22] 吴 贤,王海波,娄朝胜,等.益胃扶正汤对气虚血瘀型胃癌前病变患者的疗效及其相关机理的研究[J].中华全科医学,2021,19(6):1017-1021.
[23] 于 勇,黄雅慧,赵唯含,等.益气活血法对慢性萎缩性胃炎癌前病变Ki-67和肿瘤标记物的影响[J].广州中医药大学学报,2023,40(2):329-335.
[24] 韦 唯,向 浩,李 晨.活血健脾方合薏苡仁油对大肠癌术后患者生活质量、免疫功能及炎性因子水平的影响[J].现代中西医结合杂志,2020,29(18):1987-1989.
[25] 孟令凯,杨峻炜,杨 阔,等.胃转安颗粒治疗胃癌前病变气虚血瘀型患者的临床观察[J].世界中西医结合杂志,2020,15(6):1122-1125.
[26] 曾进浩,王钧冬,潘华峰,等.基于“土爰稼穑”探讨健脾方药修复干细胞“土壤”细胞外基质紊乱防治胃癌变的科学内涵[J].中国中医药信息杂志,2022,29(1):6-10.
[27] 刘 伟,杨良俊,袁冬生,等.基于网络药理学的黄芪-丹参药对治疗胃癌前病变作用机制[J].中华中医药杂志,2020,35(1):419-423.
[28] 刘 欢.加味归芍六君子汤联合阿帕替尼治疗气虚血瘀型ⅢB-Ⅳ期胃癌的临床疗效观察[D].长沙:湖南中医药大学,2022.
[29] 孙玉彰,李北平,陈 良.补中益气汤加减治疗胃癌术后化疗脾胃气虚证患者的临床观察[J].世界中西医结合杂志,2021,16(12):2308-2313.
[30] 杭 丽,张雪娇,卢 燕,等.董筠教授辨治胃癌前病变临床经验[J].中医药信息,2020,37(4):106-109.
[31] 袁星星,王炳予,杨 磊,等.丹芪祛瘀止痛颗粒对气虚血瘀型胃癌前病变患者胃黏膜组织TRAF1、4-1BB、Bcl-xL表达的影响[J].中医杂志,2017,58(13):1130-1134.
[32] 钱素婷,俞建顺,蔡丹莉,等.益气活血方对胃癌前病变大鼠胃黏膜Sonic Hedgehog信号通路的影响[J].中华中医药杂志,2021,36(1):446-451.
[33] 王国庆,刘红军,梁素芳.益气活血方联合三联疗法对气虚血瘀型慢性萎缩性胃炎患者炎性反应和血液流变学的影响[J].世界中医药,2019,14(1):182-186.
[34] 吴水清,黄建成,李达周,等.OLGA及OLGIM分期系统对1790例慢性萎缩性胃炎患者胃癌风险的评估价值[J].陕西医学杂志,2021,50(6):756-758.
[35] 宋 卓,杨宇飞,孙凌云,等.胃肠恶性肿瘤以脾虚为核心病机的理论与实践探讨[J].世界中医药,2021,16(9):1357-1363.

相似文献/References:

[1]蔺焕萍,王 峰,周晓燕,等.李守朝教授治疗胃癌前病变临证经验拾萃[J].陕西中医,2021,(1):103.[doi:DOI:10.3969/j.issn.1000-7369.2020.01.028]
　LIN Huanping,WANG Feng,ZHOU Xiaoyan,et al.Professor LI Shouchao's experience in the treatment of precancerous lesions of gastric cancer[J].,2021,(12):103.[doi:DOI:10.3969/j.issn.1000-7369.2020.01.028]
[2]宋 健,孟凯强,雷根平,等.名中医沈舒文使用动物类中药治疗胃癌前病变临床经验[J].陕西中医,2024,(2):256.[doi:DOI:10.3969/j.issn.1000-7369.2024.02.024]
[3]沈家林,许雨晴,曹若彤,等.金果胃康胶囊对胃癌前病变模型大鼠胃黏膜ULK1/AMPK/mTOR信号通路的影响[J].陕西中医,2024,(4):446.[doi:DOI:10.3969/j.issn.1000-7369.2024.04.003]
　SHEN Jialin,XU Yuqing,CAO Ruotong,et al.Effect of Jinguo Weikang capsule on ULK1/AMPK/mTOR signaling pathway in gastric mucosa of precancerous lesions of gastric cancer model rats[J].,2024,(12):446.[doi:DOI:10.3969/j.issn.1000-7369.2024.04.003]
[4]陈佳永,庞 延,潘朝锌,等.基于心肌能量代谢探讨中医药防治心力衰竭研究进展[J].陕西中医,2024,(7):1002.[doi:DOI:10.3969/j.issn.1000-7369.2024.07.032]
　CHEN Jiayong,PANG Yan,PAN Chaoxin,et al.Research progress of traditional Chinese medicine in prevention and treatment of heart failure based on myocardial energy metabolism[J].,2024,(12):1002.[doi:DOI:10.3969/j.issn.1000-7369.2024.07.032]
[5]张高来,闻新丽.基于联合辨证论治胃癌前病变临床思维与经验[J].陕西中医,2024,(8):1101.[doi:DOI:10.3969/j.issn.1000-7369.2024.08.020]
[6]刘 桐,孙鹤员,唐 强,等.基于圆运动理论探析胃癌前病变的病机与治疗[J].陕西中医,2025,46(4):508.[doi:DOI:10.3969/j.issn.1000-7369.2025.04.016]
　LIU Tong,SUN Heyuan,TANG Qiang,et al.Discussion of the pathogenesis and treatment of gastric precancerous lesions based on circular motion theory[J].,2025,46(12):508.[doi:DOI:10.3969/j.issn.1000-7369.2025.04.016]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81774257); 北京中医医院课题(LYZD202207)
更新日期/Last Update: 2023-12-08