[1]唐业妮,唐宏亮,梁英业,等.基于Ca2+调控星形胶质细胞探讨推拿对神经病理性疼痛镇痛机制研究进展[J].陕西中医,2024,(12):1713-1717.[doi:DOI:10.3969/j.issn.1000-7369.2024.12.028]
　TANG Yeni,TANG Hongliang,LIANG Yingye,et al.Research progress on analgesic mechanism of massage on neuropathic pain based on Ca2+regulation of astrocytes[J].,2024,(12):1713-1717.[doi:DOI:10.3969/j.issn.1000-7369.2024.12.028]
点击复制

基于Ca2+调控星形胶质细胞探讨推拿对神经病理性疼痛镇痛机制研究进展
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年12期
页码:
1713-1717
栏目:
综 述
出版日期:
2024-12-05

文章信息/Info

Title:
Research progress on analgesic mechanism of massage on neuropathic pain based on Ca2+regulation of astrocytes
作者:
唐业妮1; 唐宏亮2; 梁英业3; 庞 军3
(1.广西中医药大学,广西 南宁 530000; 2.广西中医药大学附属防城港医院,广西 防城港538000; 3.广西中医药大学第一附属医院,广西 南宁 530000)
Author(s):
TANG Yeni; TANG Hongliang; LIANG Yingye; PANG Jun
(Guangxi University of Traditional Chinese Medicine,Nanning 530000,China)
关键词:
神经病理性疼痛;  钙离子;  星形胶质细胞;  推拿;  研究进展;  机制
Keywords:
Neuropathic pain;  Ca2+;  Astrocytes;  Tuina;  Research progress;  Mechanism
分类号:
R 741
DOI:
DOI:10.3969/j.issn.1000-7369.2024.12.028
文献标志码:
A
摘要:
神经病理性疼痛(NPP)是一种难治性疼痛综合征,由躯体感觉神经系统的损伤或疾病引起,以自发性疼痛、痛觉过敏、异常疼痛和感觉异常为特征。星形胶质细胞作为中枢神经系统中最大、数量最多的神经胶质细胞,当其被激活为反应性星形胶质细胞后,对神经病理性疼痛进展起到重大影响,而Ca2+信号是反应性星形胶质细胞的重要参与者。因此,抑制星形胶质细胞活化有可能是缓解神经病理性疼痛的潜在策略。目前临床治疗神经病理性疼痛的方式主要是应用镇痛药物,但往往因现有镇痛药物的疗效有限和不良反应而复杂化。推拿作为一种传统中医治疗手段,因其不良反应少、疗效明显,在疼痛患者中被广泛使用。且推拿对Ca2+信号、星形胶质细胞活化的调控作用也有相关文献记载,但推拿的镇痛机制尚不清楚。因此笔者通过搜索有关文献,分析总结推拿干预Ca2+信号、抑制星形胶质细胞活化,减轻神经病理性疼痛相关信号通路的研究进展。
Abstract:
Neuropathic pain(NPP)is a refractory pain syndrome caused by injury or disease of the somatosensory nervous system,which is characterized by spontaneous pain,hyperalgesia,abnormal pain and paresthesia.As the largest and largest number of glial cells in the central nervous system,astrocytes play an important role in the progression of neuropathic pain when they are activated into reactive astrocytes,and Ca2+ signaling is an important participant in reactive astrocytes.Therefore,inhibition of astrocyte activation may be a potential strategy to alleviate neuropathic pain.At present,the clinical treatment of neuropathic pain is mainly analgesic drugs,but it is often complicated by the limited efficacy and adverse side effects of existing analgesic drugs.As a traditional Chinese medicine treatment,massage is widely used in patients with pain because of its less adverse reactions and obvious curative effect.The regulation of massage on Ca2+ signal and astrocyte activation has also been recorded in the literature,but the analgesic mechanism of massage is still unclear.Therefore,the author analyzed and summarized the research progress of massage intervention in Ca2+ signaling,inhibition of astrocyte activation,and reduction of neuropathic pain-related signaling pathways by searching relevant literature.

参考文献/References:

[1] COHEN S P,VASE L,HOOTEN W M.Chronic pain:An update on burden,best practices,and new advances[J].Lancet,2021,397(10289):2082-2097.
[2] PETZKE F,TOLLE T,FITZCHARLES M A,et al.Cannabis-based medicines and medical cannabis for chronic neuropathic pain[J].CNS Drugs,2022,36(1):31-44.
[3] VON BARTHELD C S,BAHNEY J,HERCUIANO-HOUZEL S.The search for true numbers of neurons and glial cells in the human brain:A review of 150 years of cell counting[J].Comp Neurol,2016,524(18):3865-3895.
[4] HERCULANO-HOUZEL S.The glia/neuron ratio:How it varies uniformly across brain structures and species and what that means for brain physiology and evolution[J].Glia,2014,62(9):1377-1391.
[5] 史文哲,罗文哲,宋汉君,等.大鼠脑外伤后星形胶质细胞及血清中相关蛋白随时间表达变化研究[J].陕西医学杂志,2022,51(8):934-938.
[6] GUDKOV S V,BURMISTROV D E,KONDAKOVA E V,et al.An emerging role of astrocytes in aging/neuroinflammation and gut-brain axis with consequences on sleep and sleep disorders[J].Ageing Res Rev,2023,83:101775.
[7] LI D Y,GAO S J,SUN J,et al.Notch signaling activation contributes to paclitaxel-induced neuropathic pain via activation of A1 astrocytes[J].Eur J Pharmacol,2022,928:175130.
[8] HUANG H Z,LYU L J,LIU Z,et al.Intervention effect of Tuina pressing and kneading the Huantiao(GB30)acupoint on NF-κB p65 protein at spinal cord dorsal horn in sciatica rats[J].Zhongguo Gushang,2023,36(6):519-524.
[9] 张幻真,林志刚,陈乐春,等.推拿按揉法对慢性坐骨神经挤压伤大鼠脊髓背角星形胶质细胞和神经元的影响[J].中医康复,2024,1(4):1-5.
[10] CABRAL-COSTA J V,KOWALTOWSKI A J.Mitochondrial Ca2+ handling as a cell signaling hub:Lessons from astrocyte function[J].Essays Biochem,2023,67(1):63-75.
[11] LIA A,HENRIQUES V J,ZONTA M,et al.Calcium signals in astrocyte microdomains,a decade of great advances[J].Front Cell Neurosci,2021,15:673433.
[12] GUI Y,LI A,ZHANG J,et al.α-asarone alleviated chronic constriction injury-induced neuropathic pain through inhibition of spinal endoplasmic reticulum stress in an liver X receptor-dependent manner[J].Anesth Analg,2018,127(3):775-783.
[13] SANTULLI G,LEWIS D,DESGEORGES A,et al.Ryanodine receptor structure and function in health and disease[J].Subcell Biochem,2018,87:329-352.
[14] LU N,CHENG L Z,ZHANG Y Q,et al.Involvement of ryanodine receptors in tetanic sciatic stimulation-induced long term potentiation of spinal dorsal horn and persistent pain in rats[J].J Neurosci Res,2012,90(5):1096-1104.
[15] SHERWOOD M W,ARIZONO M,HISATSUNE C,et al.Astrocytic IP3Rs:Contribution to Ca2+ signalling and hippocampal LTP[J].Glia,2017,65(3):502.
[16] GRABMAYR H,ROMANIN C,FAHRNER M.STIM proteins:An ever-expanding family[J].Int J Mol Sci,2020,22(1):378.
[17] ZHANG Q,WANG C,HE L.ORAI Ca2+ channels in cancers and therapeutic interventions[J].Biomolecules,2024,14(4):417.
[18] YOAST R E,EMRICH S M,TREBAK M.The anatomy of native CRAC channel(s)-science direct[J].Curr Opin Physiol,2020,17:89-95.
[19] TOTH A B,HORI K,NOVAKOVIC M M,et al.CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission[J].Sci Signal,2019,12(582):5450.
[20] MOLNAR T,YARISHKIN O,IUSO A,et al.Store-operated calcium entry in müller glia is controlled by synergistic activation of TRPC and orai channels[J].J Neurosci,2016,36(11):3184-3198.
[21] GANDINI M A,ZAMPONI G W.Voltage-gated calcium channel nanodomains:Molecular composition and function[J].FEBS J,2022,289(3):614-633.
[22] WESTHOFF M,DIXON R E.Mechanisms and regulation of cardiac CaV1.2 trafficking[J].Int J Mol Sci,2021,22(11):5927.
[23] ZAMORA N N,CHELI V T,SANTIAGO D A,et al.Deletion of voltage-gated calcium channels in astrocytes during demyelination reduces brain inflammation and promotes myelin regeneration in mice[J].J Neurosci,2020,40(17):3332-3347.
[24] 艾林,高鹏,李恺,等.冷刺激磨牙对TRPM8基因敲除小鼠脑干中c-Fos表达的影响[J].陕西医学杂志,2021,50(2):135-138.
[25] DVORNIKOVA K A,PLATONOVA O N,BYSTROVA E Y.The role of TRP channels in sepsis and colitis[J].Int J Mol Sci,2024,25(9):4784.
[26] 武玉刚,朱玉龙,马红霞.祛风止痉胶囊对支气管哮喘大鼠气道炎症及TRPV1通路的影响[J].陕西中医,2024,45(4):463-467.
[27] CHEN Y,GEIS C,SOMMER C.Activation of TRPV1 contributes to morphine tolerance:Involvement of the mitogen activated protein kinase signaling pathway[J].J Neurosci,2008,28(22):5836-5845..
[28] LI M,XU J,LI L,et al.Voluntary wheel exercise improves glymphatic clearance and ameliorates colitis associated cognitive impairment in aged mice by inhibiting TRPV4-induced astrocytic calcium activity[J].Exp Neurol,2024,376:114770.
[29] SONG S,WANG Q,QU Y,et al.Pregabalin inhibits purinergic P2Y2 receptor and TRPV4 to suppress astrocyte activation and to relieve neuropathic pain[J].Eur J Pharmacol,2023,960:176140.
[30] ROMANI P,VALCARCEL-JIMENEZ L,FREZZA C,et al.Crosstalk between mechanotransduction and metabolism[J].Nat Rev Mol Cell Biol,2021,22(1):22-38.
[31] CHI S,CUI Y,WANG H,et al.Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions[J].Neuron,2022,110(18):2984-2999.
[32] GOMEZ-CRUZ C,FERNANDEZ-DE L T M,LACHOWSKI D,et al.Mechanical and functional responses in astrocytes under alternating deformation modes using magneto active substrates[J].Adv Mater,2024,36(26):e2312497.
[33] BELTRAN-LOBO P,REID M J,JIMENEZ-SANCHEZ M,et al.Astrocyte adaptation in Alzheimer's disease:A focus on astrocytic P2X7R[J].Essays Biochem,2023,67(1):119-130.
[34] 高芳芳,李婷婷,崔艺敏,等.针刺作用下嘌呤受体P2X7对神经病理性疼痛的作用[J].陕西中医,2023,44(2):271-273.
[35] YANG P P,CHUEH S H,SHIE H L,et al.Effects of hericium erinaceus mycelium extracts on the functional activity of purinoceptors and neuropathic pain in mice with L5 spinal nerve ligation[J].Evidence Based Complement and Alternat Med,2020,2020(3):1-12.
[36] SOLAN J L,LAMPE P D.Src regulation of Cx43 phosphorylation and gap junction turnover[J].Biomolecules,2020,10(12):1596.
[37] PANATTONI G,AMORIELLO R,MEMO C,et al.Diverse inflammatory threats modulate astrocytes Ca2+ signaling via connexin43 hemichannels in organotypic spinal slices[J].Mol Brain,2021,14(1):159.
[38] LOPEZ X,PALACIOS-PRADO N,GUIZA J,et al.A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKⅡ[J].Proc Natl Acad Sci U S A,2021,118(32):e2108967118.

相似文献/References:

[1]钟青华,杨 松,孟 灵,等.电针颈夹脊穴对神经病理性疼痛大鼠脊髓背角谷氨酸受体及趋化因子受体表达水平的影响[J].陕西中医,2022,(5):564.[doi:DOI:10.3969/j.issn.1000-7369.2022.05.005]
　ZHONG Qinghua,YANG Song,MENG Ling,et al.Effects of electroacupuncture at cervical Jiaji point on the expression levels of CCR2,CX3CR1,NMDA and AMPA in spinal dorsal horn of rats with neuropathic pain[J].,2022,(12):564.[doi:DOI:10.3969/j.issn.1000-7369.2022.05.005]
[2]廖承成,尹瑞文,张洪卫,等.基于JNK/p38 MAPK/NF-κB信号通路探究八桂止痛散对脂多糖诱导脊髓星形胶质细胞凋亡的影响[J].陕西中医,2024,(4):457.[doi:DOI:10.3969/j.issn.1000-7369.2024.04.005]
　LIAO Chengcheng,YIN Ruiwen,ZHANG Hongwei,et al.The impact of Bagui Zhitong powder on LPS-induced apoptosis of spinal cord astrocytes based on the JNK/p38 MAPK/NF-κB signaling pathway[J].,2024,(12):457.[doi:DOI:10.3969/j.issn.1000-7369.2024.04.005]
[3]萨出拉,杨震杰,于天源,等.推拿通过NF-κB/GT通路对minor CCI大鼠的镇痛启动机制研究[J].陕西中医,2024,(8):1016.[doi:DOI:10.3969/j.issn.1000-7369.2024.08.002]
　Sachula,YANG Zhenjie,YU Tianyuan,et al.Explore the analgesic initiation mechanism of tuina in minor CCI rats with NF-κB/GT pathway as the main pathway[J].,2024,(12):1016.[doi:DOI:10.3969/j.issn.1000-7369.2024.08.002]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82074574,82205305,82260976,82374611); 广西自然科学基金资助项目(2023GXNSFDA026012)
更新日期/Last Update: 2024-12-05