[1]胡天祺,杨梦琪,杨 红,等.益气养阴方对卵巢癌术后患者化疗不良反应及生存质量的影响[J].陕西中医杂志,2021,(4):434-437.[doi:DOI:10.3969/j.issn.1000-7369.2020.04.007]
　HU Tianqi,YANG Mengqi,YANG Hong,et al.Effect of Yiqi Yangyin recipe on the adverse reaction effects and quality of life in patients with ovarian cancer undergoing chemotherapy[J].,2021,(4):434-437.[doi:DOI:10.3969/j.issn.1000-7369.2020.04.007]
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益气养阴方对卵巢癌术后患者化疗不良反应及生存质量的影响
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《陕西中医》杂志[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年4期
页码:
434-437
栏目:
临床研究
出版日期:
2021-04-05

文章信息/Info

Title:
Effect of Yiqi Yangyin recipe on the adverse reaction effects and quality of life in patients with ovarian cancer undergoing chemotherapy
作者:
胡天祺; 杨梦琪; 杨 红; 林 益; 钱 麟
(上海中医药大学附属曙光医院,上海201203)
Author(s):
HU Tianqi; YANG Mengqi; YANG Hong; LIN Yi; QIAN Lin
(Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
关键词:
卵巢癌;  益气养阴方;  化疗;  不良反应;  生存质量
Keywords:
Ovarian cancer;  Yiqi Yangyin recipe;  Chemotherapy;  Adverse reactions;  Quality of life
分类号:
R 737.31
DOI:
DOI:10.3969/j.issn.1000-7369.2020.04.007
文献标志码:
A
摘要:
目的:观察益气养阴方对卵巢癌术后患者行化疗治疗的不良反应及生存质量的影响。方法:将经全面手术的64例卵巢癌术后Ⅰ-Ⅲ期患者采用简单随机化分组法分为观察组和对照组各32例。对照组予紫杉醇+铂类静脉给药,治疗6个疗程,观察组在对照组治疗的基础上在化疗间歇期内口服益气养阴方。每次化疗前及化疗后第3天测血常规及肝肾功能,并记录胃肠道反应以测定患者不良反应(白细胞、中性粒细胞、血红蛋白降低; 腹泻、恶心呕吐等)情况。并采用卡氏评分(Karnofsky)及癌症生命质量评分(EORTC QLQ-C30)评价两组患者化疗前后生存质量,同时观察两组的中医证候积分变化情况。结果:观察组不良反应(白细胞、中性粒细胞、血红蛋白降低、腹泻、恶心呕吐等)均明显低于对照组(P<0.05); 两组化疗后在卡氏评分、QLQ-C30评分差异均具有统计学意义(P<0.05); 治疗后观察组在气阴两虚证证侯积分及血瘀证证候积分上均低于对照组(P<0.05)。结论:益气养阴方可降低卵巢癌术后化疗患者的化疗不良反应,提高患者生活质量与人体功能,改善患者中医证候。
Abstract:
Objective:To observe the effect of Yiqi Yangyin recipe on the adverse reactions and quality of life in patients with ovarian cancer after operation.Methods:64 patients with stage Ⅰ-Ⅲ ovarian cancer who underwent comprehensive surgery were divided into experimental group(32 cases)and control group(32 cases)by simple randomization method.The control group was treated with paclitaxel plus platinum in vein for 6 courses,and the experimental group was treated with Yiqi Yangyin recipe in the intermittent period of chemotherapy on the basis of the control group.Blood routine test,liver and kidney function were measured before and 3rd days after chemotherapy,and gastrointestinal reactions were recorded to determine the side effects(WBC,neutrophil,hemoglobin reduction; diarrhea,nausea and vomiting,etc.).Karnofsky and EORTC QLQ-C30 were used to evaluate the quality of life of the patients in the two groups before and after chemotherapy,and the changes of TCM syndrome scores in the two groups were observed.Results:The adverse reaction(WBC,neutrophil,hemoglobin reduction,diarrhea,nausea and vomiting,etc.)in the experimental group were significantly lower than those in the control group(P<0.05).Conclusion:Yiqi Yangyin recipe can reduce the adverse reaction of chemotherapy,improve the quality of life and human function,and improve the syndrome of Qi Yin deficiency and blood stasis.

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备注/Memo

备注/Memo:
基金项目:上海市科学技术委员会项目(18401904200); 上海市浦东新区中医办院内制剂再评价项目(PDYNCD2015-27); 齐聪上海市名老中医学术经验研究工作室项目(SHGZS-2017026)
更新日期/Last Update: 2021-04-09