[1]周 艳,王 顺,白 妍.从肝论治帕金森病非运动症状[J].陕西中医,2024,(2):230-234.[doi:DOI:10.3969/j.issn.1000-7369.2024.02.018]
 ZHOU Yan,WANG Shun,BAI Yan.Treatment non-motor symptoms of Parkinson 's disease from liver[J].,2024,(2):230-234.[doi:DOI:10.3969/j.issn.1000-7369.2024.02.018]
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从肝论治帕金森病非运动症状
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年2期
页码:
230-234
栏目:
学术探讨
出版日期:
2024-02-05

文章信息/Info

Title:
Treatment non-motor symptoms of Parkinson 's disease from liver
作者:
周 艳1王 顺2白 妍3
(1.黑龙江中医药大学,黑龙江 哈尔滨150040; 2.黑龙江中医药大学第二临床医学院,黑龙江 哈尔滨150001; 3.黑龙江省中医药科学院研究所,黑龙江 哈尔滨150036)
Author(s):
ZHOU YanWANG ShunBAI Yan
(Heilongjiang University of Chinese Medicine,Harbin 150040,China)
关键词:
帕金森病 非运动症状 针刺 疏肝理气 痰浊
Keywords:
Parkinson's disease Non-motor symptoms Liver Acupuncture Soothe the liver and regulate qi Phlegm
分类号:
R 741
DOI:
DOI:10.3969/j.issn.1000-7369.2024.02.018
文献标志码:
A
摘要:
基于肝的生理特点,从风、火、痰、瘀、虚五种病机证素对帕金森病非运动症状进行探讨。由于患者素体阴精不足,或阴血亏虚,阴虚不能制阳,阳亢化风; 或肝郁克脾,脾运失司,痰湿内生; 或肝气郁滞,阻碍血行; 或痰瘀留滞经络而致病。阴精、肝血不足,筋脉失养为虚; 痰浊、血瘀阻滞经络为实。治则以平肝滋阴、疏肝清热、理气化痰、活血养血为主,中药和针刺并用。肝风内扰,以平肝为主,兼以滋阴,选方镇肝熄风汤; 肝火伤阴,以清热为主,兼以养阴,选方丹栀逍遥散; 气滞痰阻,以理气为主,兼以化痰,选方柴胡加龙骨牡蛎汤; 气滞血瘀,以理气为主,兼以活血,选方血府逐瘀汤; 肝血亏虚,以补血为主,兼以柔肝,选方补肝汤。针刺辨病与辨证相结合,进行加减配穴。
Abstract:
Based on the physiological characteristics of the liver,this article discusses the non-motor symptoms of Parkinson 's disease from the five pathogenesis elements of wind,fire,phlegm,blood stasis and deficiency.Insufficient of yin essence can not control yang,yang hyperactivity and wind; liver depression restrains spleen,spleen movement disorder,phlegm endogenous; liver qi stagnation,hinder blood; phlegm and blood stasis,retention in meridians.Due to deficiency,yin essence,liver blood insufficient,tendon and pulse malnutrition; because of solid,phlegm,blood stasis block meridians.Therefore,the treatment is traditional Chinese medicine and acupuncture and mainly based on calming liver and nourishing yin,soothing liver and clearing heat,regulating qi and resolving phlegm,promoting blood circulation and nourishing blood.The liver wind internal disturbance,mainly to calm the liver,and to nourish yin,choose Zhengan Xifeng decoction; the liver fire persecutes yin,mainly clearing heat,and nourishing yin,select prescription Danzhi Xiaoyao powder; qi stagnation and phlegm obstruction,mainly to regulate qi,combined with phlegm,apply Chaihu plus Longgu Muli decoction.Qi stagnation and blood stasis,mainly to regulate qi,and to promote blood circulation,use Xuefu Zhuyu decoction; liver blood deficiency,mainly to tonify blood,and to soften the liver,employ Bugan decoction.Acupuncture is combined with disease differentiation and syndrome differentiation to add and subtract acupoints.

参考文献/References:

[1] NABIZADEH F,PIRAHESH K,KHALILI E.Olfactory dysfunction is associated with motor function only in tremor-dominant Parkinson's disease[J].Neurol Sci,2022,43(7):4193-4201.
[2] 韦波.“调神畅情”针法对PD胃肠功能障碍模型大鼠不同部位α-syn含量影响的研究[D].哈尔滨:黑龙江省中医药科学院,2020.
[3] NAKAMORI H,NODA K,MITSUI R,et al.Role of enteric dopaminergic neurons in regulating peristalsis of rat proximal colon[J].Neurogastroenterol Motil,2021,33(9):14127.
[4] BANG Y,LIM J,CHOI H J.Recent advances in the pathology of prodromal non-motor symptoms olfactory deficit and depression in Parkinson's disease:Clues to early diagnosis and effective treatment[J].Archives of Pharmacal Research,2021,44(6):588-604.
[5] WEINTRAUB D,TROSTER A I,MARRAS C,et al.Initial cognitive changes in Parkinson's disease[J].Movement Disorders,2018,33(4):511-519.
[6] 弥婉军,王晓娟.胰高血糖素样肽-1蛋白对帕金森病氧化应激损伤的保护作用及机制研究[J].陕西医学杂志,2021,50(4):395-397.
[7] SCOTT B M,EISINGER R S,BURNS M R,et al.Co-occurrence of apathy and impulse control disorders in Parkinson disease[J].Neurology,2020,95(20):2769-2780.
[8] GOLDMAN J G,SIEG E.Cognitive impairment and dementia in Parkinson disease[J].Clin Geriatr Med,2020,36(2):365-377.
[9] 黄少东,梁健芬,张兴博,等.加味五虎追风散对肾虚血瘀型帕金森病非运动症状影响的临床研究[J].上海中医药杂志,2021,55(5):50-53.
[10] 吴同越,钱小溪,伊慧敏,等.基于朱丹溪“阴难成易亏”观点探讨帕金森病证治[J].福建中医药,2022,53(4):31-33.
[11] 杨兴茂,霍青.从虚、痰、瘀、毒浅析帕金森病病机[J].湖南中医杂志,2021,37(8):129-131.
[12] 唐丽雯,许山山,宫凤英,等.阖阳明、补中气之法治疗帕金森病经验[J].环球中医药,2021,14(10):1836-1838.
[13] 尹程琳,吴清明.吴清明从瘀辨治老年顽固性失眠经验[J].湖南中医杂志,2019,35(4):21-25.
[14] 马金鸽,谢晶日.谢晶日教授辨治失眠经验[J].云南中医中药杂志,2023,44(3):1-4.
[15] 赵晓娟,权青云,孟宏涛,等.α-突触核蛋白与帕金森病伴发快速眼动期睡眠行为障碍相关性研究[J].陕西医学杂志,2022,51(2):191-194.
[16] 荣华,张静艳,刘京,等.牛膝-白芍对肝阳上亢型帕金森病小鼠脑组织氧化应激的影响[J].中国药房,2022,33(18):2192-2197.
[17] 王晓丽,朱兰芹,綦艳秋,等.镇肝熄风汤对帕金森病肝阳上亢证模型大鼠脑组织谷胱甘肽抗氧化系统的影响[J].中医学报,2018,33(7):1289-1293.
[18] 吴成举,英锡相,陈靖,等.针刺疗法对帕金森病大鼠黑质神经元凋亡蛋白Bcl-2、bax的影响[J].陕西中医,2020,41(1):8-11,133.
[19] 马振旺,梁浩,赵兵,等.透穴刺法对帕金森病焦虑大鼠杏仁核TNF-α和IL-10表达的影响[J].陕西中医,2021,42(9):1171-1174.
[20] 刘蔚,曹俊岭,荆志伟,等.柴胡加龙骨牡蛎汤对帕金森病伴发抑郁模型大鼠的神经保护作用及对AMPK/mTOR信号通路的影响[J].中国实验方剂学杂志,2022,28(8):21-29.
[21] 刘金粉.基于脑肠轴理论柴胡加龙骨牡蛎汤加减治疗帕金森病(痰热风动型)的临床观察[D].济南:山东中医药大学,2021.
[22] 李亚楠,汪瑶,张小蕾,等.电针对帕金森病小鼠便秘症状的影响[J].北京中医药大学学报,2022,45(1):102-108.
[23] 韦晓芸,胡玉英,莫雪妮,等.胡玉英基于多靶点-细胞凋亡用真武汤合血府逐瘀汤辨治血水同病之帕金森病[J].内蒙古中医药,2020,39(2):61-64.
[24] 李伦甘,胡玉英.中医药干预对帕金森病细胞凋亡影响的研究进展[J].陕西中医,2021,42(2):262-264.
[25] 赵蕊,马心锋,王共强,等.养肾止颤汤对帕金森综合征患者运动症状的干预研究[J].中医药临床杂志,2021,33(4):719-722.
[26] 孙英,潘佳慧,张方圆,等. 针灸治疗帕金森病非运动症状的Meta分析[J].广州中医药大学学报, 2023, 40(2):516-525.
[27] 李聪,刘倩,罗万新,等. 基于Cite Space的针刺治疗帕金森病可视化分析[J].中医药导报,2023,29(1):155-161.
[28] 刘爱国,吴秀玲,卢宝全,等. 针灸联合西医常规治疗帕金森病疲劳的临床观察[J].河北中医, 2023, 45(1):106-109.
[29] 王艳,马奎军,朱继民,等. 帕金森病睡眠障碍的中西医研究进展[J].新疆中医药,2022,40(6):102-105.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81674091)
更新日期/Last Update: 2024-02-07