[1]孙境孺,李竹英.NF-κB信号通路在肺部疾病中的作用研究进展及中医药干预现状[J].陕西中医,2022,(7):972-974,978.[doi:DOI:10.3969/j.issn.1000-7369.2022.07.039]
　SUN Jingru,LI Zhuying.Research progress of role of NF-κB signaling pathway in lung diseases and the current situation of traditional Chinese medicine intervention[J].,2022,(7):972-974,978.[doi:DOI:10.3969/j.issn.1000-7369.2022.07.039]
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NF-κB信号通路在肺部疾病中的作用研究进展及中医药干预现状
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年7期
页码:
972-974,978
栏目:
综 述
出版日期:
2022-07-05

文章信息/Info

Title:
Research progress of role of NF-κB signaling pathway in lung diseases and the current situation of traditional Chinese medicine intervention
作者:
孙境孺1; 李竹英2
(1.黑龙江中医药大学,黑龙江 哈尔滨 150040; 2.黑龙江中医药大学附属第一医院呼吸科,黑龙江 哈尔滨 150040)
Author(s):
SUN Jingru; LI Zhuying
(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)
关键词:
哮喘;  慢性阻塞性肺疾病;  急性肺损伤;  NF-κB信号通路;  炎症反应
Keywords:
Asthma;  Chronic obstructive pulmonary disease;  Acute lung injury;  Nuclear factor-kappa B signaling pathway;  Inflammatory response
分类号:
R 563
DOI:
DOI:10.3969/j.issn.1000-7369.2022.07.039
文献标志码:
A
摘要:
NF-κB是经典信号通路,在肺部疾病中具有中心调控作用。通过查阅近年中医药作用于NF-κB信号通路治疗炎症性肺部疾病相关文献,对NF-κB信号通路的组成与激活、与炎症性肺部疾病的关系和中医药干预对NF-κB信号通路的影响进行阐述,发现NF-κB信号通路在细胞炎症反应和免疫应答过程中扮演重要角色,中药可调控NF-κB信号通路阻断或抑制机体炎症反应,可以为肺部疾病的临床治疗与新药开发提供理论依据。
Abstract:
NF-κB signaling pathway is a classical signaling pathway,which plays central regulatory role in lung diseases.We refer to the relevant research reports on the treatment of lung diseases by TCM intervention NF-κB signaling pathway in recent years.By elaborating the composition and activation of signal pathway,the relationship with lung disease and the effect of traditional Chinese medicine intervention on NF-κB signaling pathway,we found NF-κB signaling pathway plays an important role in cellular inflammatory response and immune response.Traditional Chinese medicine can regulate NF-κB signaling pathway blocks or suppresses inflammatory response.It can provide theoretical basis for clinical treatment and new drug development of pulmonary diseases.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助面上项目(82074365)
更新日期/Last Update: 2022-07-07