[1]侯红霞,张春红.熄风通络汤联合西药治疗对高血压患者血管内皮功能的影响*[J].陕西中医,2019,(7):875-878.
　HOU Hongxia,ZHANG Chunhong..Effects of Xifeng Tongluo decoction combined with western medicine on vascular endothelial function in patients with hypertension[J].,2019,(7):875-878.
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熄风通络汤联合西药治疗对高血压患者血管内皮功能的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年7期
页码:
875-878
栏目:
临床研究
出版日期:
2019-07-05

文章信息/Info

Title:
Effects of Xifeng Tongluo decoction combined with western medicine on vascular endothelial function in patients with hypertension
文章编号:
DOI:10.3969/j.issn.1000-7369.2019.07.017
作者:
侯红霞; 张春红
河南省三门峡市中心医院药学部（三门峡472000）
Author(s):
HOU Hongxia; ZHANG Chunhong.
Department of Pharmacy,Sanmenxia Central Hospital in Henan Province(Sanmenxia 472000)
关键词:
高血压; 熄风通络汤; 血管内皮功能; 血脂; 一氧化氮; 血清内皮素
Keywords:
Key words Hypertension; Xifeng Tongluo decoction; Vascular endothelial function; Blood lipids; Nitric oxide; Serum levels of endothelin-1
分类号:
R544.1
文献标志码:
A
摘要:
摘 要 目的:探讨熄风通络汤联合西药治疗对原发性高血压(EH)患者血管内皮功能的影响。方法:遴选184例EH患者随机分为对照组(n=92)和观察组(n=92)，对照组给予常规西药治疗，观察组在以上西医治疗基础上给予熄风通络汤治疗，观察两组治疗前及治疗28 d后的血压、中医症状积分，临床疗效，治疗前及治疗28 d后的血管内皮功能及血脂指标变化。结果:治疗28 d后，两组舒张压(DBP)、收缩压(SBP)值显著下降(P＜0.05)，中医症状积分显著减少(P＜0.05)，观察组变化幅度显著大于对照组(P＜0.05)。组间对比临床总有效率发现，观察组(92.39%)显著高于对照组(80.43%)(P＜0.05)。治疗28 d后，两组血清内皮素-1(ET-1)、超敏C反应蛋白(hs-CRP)水平显著降低(P＜0.05)，一氧化氮(NO)水平显著升高(P＜0.05)，观察组变化幅度显著大于对照组(P＜0.05)。治疗28 d后，两组血清三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)显著降低，高密度脂蛋白胆固醇(HDL-C)水平显著升高(P＜0.05)，观察组以上血脂指标除HDL-C之外的变化幅度显著大于对照组(P＜0.05)。结论:熄风通络汤联合西药治疗EH患者疗效确切，可改善患者血压水平和相关症状，提高血管内皮舒张功能，有效调节血脂水平。
Abstract:
Abstract Objective:To explore the effects of Xifeng Tongluo decoction combined with western medicine on vascular endothelial function in patients with essential hypertension(EH).Methods:A total of 184 patients with EH were randomly divided into control group(n=92) and observation group(n=92).Control group was treated with conventional western medicine,and observation group was treated with Xifeng Tongluo decoction on the basis of above western medicine treatment.Blood pressure and TCM symptoms scores before treatment and after 28 d of treatment,clinical efficacy,vascular endothelial function and blood lipids indexes before treatment and after 28 d of treatment were observed in the two groups.Results:After 28 d of treatment,the values of diastolic blood pressure(DBP) and systolic blood pressure(SBP) were significantly decreased(P＜0.05),and the scores of TCM symptoms were significantly decreased(P＜0.05),and the changes in observation group were significantly greater than those in control group(P＜0.05).The total clinical effective rate in the observation group was significantly higher than that in control group(92.39% vs 80.43%)(P＜0.05).After 28 d of treatment,serum levels of endothelin-1(ET-1) and high-sensitivity C-reactive protein(hs-CRP) were significantly decreased(P＜0.05) while the nitric oxide(NO) level was significantly increased(P＜0.05),and the changes in observation group were significantly greater than those in control group(P＜0.05).After 28 d of treatment,the levels of serum triglyceride(TG),total cholesterol(TC) and low-density lipoprotein cholesterol(LDL-C) were significantly decreased while the high-density lipoprotein cholesterol(HDL-C) level was significantly increased(P＜0.05),and the changes of blood lipid indexes except HDL-C in observation group were significantly larger than those in control group(P＜0.05).Conclusion:Xifeng Tongluo decoction combined with western medicine has exact efficacy in treating EH patients,and it can improve blood pressure level and related symptoms,enhance vascular endothelial dilation function,and effectively regulate blood lipids levels.

参考文献/References:

[1] 王静怡,郑 香,吴寿岭.糖耐量异常对原发性高血压病患者血压变异性的影响[J].河北医药,2013,35(11):1681-1682. [2] 陈 鋆,龚逸炜,周晓琴,等.腺苷酸环化酶3基因多态性与原发性高血压的关联研究[J].中华心血管病杂志,2016,44(7):594-599. [3] 薛瑞文,陈 荣,路亚娥,等.综合疗法治疗风痰上扰证眩晕50例疗效观察[J].山东中医药大学学报,2015,39(2):147-148,159. [4] 刘维田,郑建辉,张国栋,等.自拟熄风通络组方联合西药治疗急性脑梗死的疗效观察[J].中西医结合心脑血管病杂志,2016,14(9):1025-1027. [5] 中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华高血压杂志,2011,3(8):701-708. [6] 国家中医药管理局.中医病证诊断疗效标准[M].南京:南大学出版社,1994:146-147. [7] 国家食品药品监督管理局.中药新药临床研究指导原则试行[M].北京：中国医药科技出版社,2002:73-77. [8] 史焕周.针刺加加味熄风通络汤联合琥珀酸美托洛尔缓释片治疗原发性高血压110例[J].中医研究,2018,31(6):59-61. [9] 黄先平,操良松.养阴熄风通络汤联合血栓通对中风偏瘫神经功能恢复影响[J].中华中医药学刊,2018,36(7):1647-1650. [10] 杨 晶.通络熄风汤加减联合瓜蒌皮注射液对急性缺血性脑卒中患者神经功能及血清H-FABP、IMA水平的影响[J].陕西中医,2018,39(7):863-865. [11] 陈晓东,孙 俊.熄风通络化瘀汤联合西药治疗高血压随机平行对照研究[J].实用中医内科杂志,2017,31(10):67-70. [12] 陈 岚,任 骞,徐 进,等.苯磺酸左旋氨氯地平对原发性高血压患者血管内皮功能的影响[J].陕西医学杂志,2016,45(2):241-242. [13] 范茂丹,周 磊,张轶男,等.不同血压模式对高血压病患者血管内皮功能及动脉硬化的影响[J].海军医学杂志,2017,38(4):313-316. [14] 邓于亮.高血压患者胰岛素抵抗与代谢综合征、心血管事件的相关性分析[J].医学临床研究,2018,35(3):489-491,494. [15] 张 奡.苯磺酸氨氯地平联合卡托普利治疗高血压合并冠心病的疗效观察[J].中国循证心血管医学杂志,2017,9(9):1127-1128.

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备注/Memo

备注/Memo:
*河南省医学科技攻关计划项目(424410031)
更新日期/Last Update: 2019-07-12